Evidence map›Paper›PMID 41009350›Full record

ArticleInternational journal of molecular sciences2025

Orange Peel-Mediated Green Synthesis of ZnO and CuO Nanoparticles: Evaluation for Antimicrobial Activity and Biocompatibility in Tissue Engineering.

Denisa-Maria Radulescu, Ionela Andreea Neacsu, Bogdan Stefan Vasile, Vasile-Adrian Surdu, Ovidiu-Cristian Oprea, Roxana-Doina Trusca, Cristina Chircov, Roxana Cristina Popescu, Cornelia-Ioana Ilie, Lia-Mara Ditu and 2 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Denisa-Maria RadulescuDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania.ORCID 0000-0002-6099-9026
Ionela Andreea NeacsuDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania.ORCID 0000-0003-3197-6455
Bogdan Stefan VasileNational Research Center for Micro and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 060042 Bucharest, Romania.ORCID 0000-0002-2267-6453
Vasile-Adrian SurduDepartment of Materials Science, Faculty of Materials Science and Engineering, Transilvania University of Brasov, 29 Eroilor Blvd., 500036 Brasov, Romania.ORCID 0000-0002-4207-5380
Ovidiu-Cristian OpreaNational Research Center for Micro and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 060042 Bucharest, Romania.ORCID 0000-0002-8145-1094
Roxana-Doina TruscaNational Research Center for Micro and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 060042 Bucharest, Romania.
Cristina ChircovDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania.ORCID 0000-0002-8695-6884
Roxana Cristina PopescuDepartment of Bioengineering and Biotechnology, Faculty of Medical Engineering, National University of Science and Technology POLITEHNICA Bucharest, Polizu 1-7, 011061 Bucharest, Romania.
Cornelia-Ioana IlieDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania.ORCID 0000-0002-5504-5156
Lia-Mara DituDepartment of Botany and Microbiology, Faculty of Biology, University of Bucharest, 060101 Bucharest, Romania.
Veronica DrumeaS.C. BIOTEHNOS S.A., Gorunului 3-5, 075100 Otopeni, Romania.ORCID 0000-0002-8947-0310
Ecaterina AndronescuDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania.ORCID 0000-0002-2226-5849

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The production of green nanomaterials has drawn considerable interest lately in the fields of tissue engineering and biomedicine. Thus, the environmentally friendly synthesis of ZnO and CuO nanoparticles (NPs) utilizing orange peel extract as a natural capping and reducing agent is the main focus of this study. Our comprehensive approach allows for a direct and systematic comparison of physicochemical attributes, biocompatibility, and antimicrobial activity under identical experimental circumstances, in contrast to other research that looked at individual nanoparticles under different conditions. The produced nanoparticles were characterized by techniques such as FTIR, XRD, SEM, TGA, and zeta potential assessment. MG-63 osteoblast-like cells, primary human dermal fibroblast BJ cells, and murine fibroblast L929 cells were used to evaluate biocompatibility using the MTT assay. The results showed dose-dependent cytotoxicity, especially above 25 µg/mL. Furthermore, both qualitative (growth inhibition zone diameter) and quantitative (minimum inhibitory concentration, MIC) techniques were used to assess the antimicrobial efficacy against

Indexed as

Anti-Infective AgentsBiocompatible MaterialsCitrus sinensisCopperMetal NanoparticlesTissue EngineeringZinc OxideAnimalsCandida albicansCell LineFibroblastsGreen Chemistry TechnologyHumansMiceMicrobial Sensitivity TestsPlant ExtractsAnti-Infective AgentsBiocompatible MaterialsCoppercupric oxidePlant ExtractsZinc Oxideantimicrobial activitybiocompatibilitybiofilm inhibitioncopper oxide nanoparticlesgreen synthesisnanoparticlestissue engineeringzinc oxide nanoparticles

Identifiers

PMID41009350
PMCPMC12469477

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.