Evidence mapPaperPMID 41009356Full record

ArticleInternational journal of molecular sciences2025

The Impact of Smoking-Associated Genetic Variants on Post-Exercise Heart Rate.

Habib Al Ashkar, Nihad Kharrat Helu, Nora Kovacs, Szilvia Fiatal, Roza Adany, Peter Piko

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Association analysis between genetic nurturing effects ofBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Habib Al AshkarDoctoral School of Health Sciences, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0009-0006-8271-2248
Nihad Kharrat HeluDoctoral School of Health Sciences, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0009-0004-3459-0173
Nora KovacsHUN-REN-UD Public Health Research Group, Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0001-9256-3756
Szilvia FiatalDepartment of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0002-2797-9621
Roza AdanyHUN-REN-UD Public Health Research Group, Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0002-9679-6669
Peter PikoDepartment of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0001-5539-907X

Funding

European Regional Development Fund GINOP-2.3.2-15-2016-00005Hungarian Academy of Sciences TK2016-78Hungarian Research Network - HUN-REN TKCS-2021/32Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences BO/00513/23/5National Laboratory for Health Security Hungary RRF-2.3.1-21-2022-00006National Research, Development and Innovation Fund EKÖP-24-4 University Research Scholarship Program of the Ministry for Culture and InnovationNational Research, Development, and Innovation Fund of Hungary Project No. 135784Tempus Public Foundation and the Hungarian Government Stipendium Hugaricum Scholarship ProgramUniversity of Debrecen University of Debrecen Program for Scientific Publication
6 · The paper itself

Abstract

Smoking has a well-established impact on cardiovascular health, notably through elevated resting heart rate and impaired autonomic regulation-both key risk factors. While nicotine's acute effects are well documented, the influence of smoking-related genetic variants on heart rate (HR) responses remains unclear. This study investigated the association between selected smoking-related single nucleotide polymorphisms (SNPs) and HR dynamics following physical exertion. A total of 661 Hungarian adults completed the YMCA 3 min step test, with HR measured at rest, immediately post-exercise, and during recovery at 5 and 10 min. Key indices included post-exercise HR (HR

Indexed as

ExerciseHeart RatePolymorphism, Single NucleotideSmokingAdultFemaleGenetic Predisposition to DiseaseHumansMaleMiddle Agedcardiovascular riskgenetic predispositiongenetic risk scoreheart rate recoverysingle nucleotide polymorphismssmokingYMCA step test

Identifiers

PMID41009356
PMCPMC12469723

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.