ArticleInternational journal of molecular sciences2025
Impaired Oxidative Stress Markers and Activities of Matrix Metalloproteinases in Plasma of Patients with Alzheimer's Disease, Emphasizing Sex and
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The Potential Use of Matrix Metalloproteinases in Alzheimer's Disease Therapy.Journal of clinical medicine · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by Aβ accumulation, tau pathology, and associated oxidative and inflammatory changes, including matrix metalloproteinase (MMP) involvement. This study investigated plasma markers of oxidative damage, carbonyl stress, antioxidant status, and activities of MMP-9 and MMP-2 in AD patients and controls. Spectrophotometric and fluorescent assays were used to assess oxidative and carbonyl stress markers, while MMP activities were measured by gelatin zymography. AD patients exhibited significantly increased protein oxidation, carbonyl stress, and GSH/GSSG ratio, along with reduced total antioxidant capacity and superoxide dismutase activity. Plasma MMP-2 activity was elevated in AD patients, whereas MMP-9 activity showed no significant difference. Notable sex-specific patterns were observed: MMP-2 activity was higher in women with AD than in control women, while MMP-9 activity was increased in men with AD compared with control men. Fructosamine levels were elevated in men regardless of AD status and in AD women versus control women.
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Registered trials
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