Evidence map›Paper›PMID 41009368›Full record

ArticleInternational journal of molecular sciences2025

Correlation Between the Proportion of Senescence-Associated β-Galactosidase-Stained CD8+ T Cells and Age: A Cross-Sectional Study in Japan.

Masaya Tsubokawa, Yoshiki Shimizu, Misato Yazaki, Shieri Shimodan, Masayuki Noguchi, Arisa Yamazaki, Tomomichi Watanabe, Makoto Ocho, Tsuyoshi Sakurada, Yoshie Hirose and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Masaya TsubokawaFANCL Research Institute, Yokohama 244-0806, Japan.
Yoshiki ShimizuFANCL Research Institute, Yokohama 244-0806, Japan.ORCID 0009-0006-6701-314X
Misato YazakiFANCL Research Institute, Yokohama 244-0806, Japan.ORCID 0000-0002-8876-291X
Shieri ShimodanFANCL Research Institute, Yokohama 244-0806, Japan.
Masayuki NoguchiFANCL Research Institute, Yokohama 244-0806, Japan.
Arisa YamazakiFANCL Research Institute, Yokohama 244-0806, Japan.
Tomomichi WatanabeFANCL Research Institute, Yokohama 244-0806, Japan.ORCID 0009-0009-2602-3896
Makoto OchoFANCL Research Institute, Yokohama 244-0806, Japan.
Tsuyoshi SakuradaFANCL Research Institute, Yokohama 244-0806, Japan.
Yoshie HiroseGinza Yoshie Clinic, Yukeikai Medical Corporation, V88 Building 5F, 2-5-11 Ginza, Chuo-ku, Tokyo 104-0061, Japan.
Jiro SaitoMedical Station Clinic, 3F Ichikawa Gakugei-dai Building, 3-12-8 Takaban, Meguro-ku, Tokyo 152-0004, Japan.
Yuri IshiiFANCL Research Institute, Yokohama 244-0806, Japan.

Funding

FANCL Co. none
6 · The paper itself

Abstract

Recently, senescent T cells in the peripheral blood have been detected using senescence-associated β-galactosidase (SA-βGal) activity and have been used as an endpoint in clinical trials. However, the epidemiological association between the abundance of SA-βGal-stained senescent CD8+ T cells and chronological age has not been fully elucidated. To examine the correlation between the proportion of SA-βGal

Indexed as

beta-GalactosidaseCD8-Positive T-LymphocytesT-Cell SenescenceAdultAge FactorsBiomarkersCross-Sectional StudiesFemaleHumansJapanMaleMemory T CellsMiddle Agedbeta-GalactosidaseBiomarkersageCD8+ T cellssenescencesenescence-associated β-galactosidase

Identifiers

PMID41009368
PMCPMC12469844

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.