Evidence map›Paper›PMID 41009374›Full record

ArticleInternational journal of molecular sciences2025

Functional Role of Single-Nucleotide Polymorphisms on IFNG and IFNGR1 in Humans with Cardiovascular Disease.

Megh Mehta, Yang Li, Smriti Parashar, Catalina Ramirez, Heather McKay, Alan Landay, Redouane Aherrahrou, Aarushi Advani, Raag Patel, Robert Kaplan and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Megh MehtaImmunology Center of Georgia, Augusta University, Augusta, GA 30912, USA.
Yang LiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA.
Smriti ParasharImmunology Center of Georgia, Augusta University, Augusta, GA 30912, USA.
Catalina RamirezDivision of Infectious Diseases, UNC School of Medicine, Chapel Hill, NC 27599, USA.ORCID 0000-0002-0872-0307
Heather McKayBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21218, USA.
Alan LandayDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA.
Redouane AherrahrouImmunology Center of Georgia, Augusta University, Augusta, GA 30912, USA.
Aarushi AdvaniMedical College of Georgia, Augusta University, Augusta, GA 30909, USA.
Raag PatelMedical College of Georgia, Augusta University, Augusta, GA 30909, USA.ORCID 0009-0005-5984-1693
Robert KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA.
Jason LazarDepartment of Medicine, SUNY Downstate Health Sciences University, Brooklyn, New York, NY 11203, USA.ORCID 0000-0002-8548-7932
Kathryn AnastosDepartment of Medicine, Montefiore Medical Center, Bronx, New York, NY 10467, USA.
David B HannaDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA.ORCID 0000-0002-1985-9865
Qibin QiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA.
Klaus LeyImmunology Center of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0001-9339-3672

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
SF Bay Area MACS/WIHS Combined Cohort StudyU01HL146242 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bradley E Aouizerat, Jennifer Cohen Price · 2019 to 2026
$36.3M
Sex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosisU01HL146193 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Stephen J Gange, Elizabeth Topper · 2019 to 2026
$35.8M
University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Savita Pahwa · 2007 to 2026
$33.8M
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center - Admin Supplement: Vision and dual sensory loss in HIV-infected older adultsU01HL146201 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Joseph B. Margolick · 2019 to 2026
$33.7M
Sex differences in the role of multi-omics in HIV-associated carotid artery atherosclerosisU01HL146204 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI David B. Hanna, Anjali Sharma · 2019 to 2026
$33.2M
MWCCS HL145241NCATS NIH HHS KL2 TR001432NCATS NIH HHS TL1 TR001431NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR001409NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1 TR003098NHLBI NIH HHS K01 HL137557NHLBI NIH HHS R01 HL121697NHLBI NIH HHS R01 HL126543NHLBI NIH HHS R01 HL140976NHLBI NIH HHS R01 HL148094NHLBI NIH HHS R35 HL145241NHLBI NIH HHS T32 HL155011NHLBI NIH HHS U01 HL146192NHLBI NIH HHS U01 HL146193NHLBI NIH HHS U01 HL146194NHLBI NIH HHS U01 HL146201NHLBI NIH HHS U01 HL146202NHLBI NIH HHS U01 HL146203NHLBI NIH HHS U01 HL146204NHLBI NIH HHS U01 HL146205NHLBI NIH HHS U01 HL146208NHLBI NIH HHS U01 HL146240NHLBI NIH HHS U01 HL146241NHLBI NIH HHS U01 HL146242NHLBI NIH HHS U01 HL146245NHLBI NIH HHS U01 HL146333NIAID NIH HHS P30 AI027767NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI050410NIAID NIH HHS P30 AI073961NIAID NIH HHS P30 AI124414NIH HHS 5R01-HL-126543-05NIH HHS 5R01-HL-140976-02NIH HHS K01-HL-137557NIH HHS R01-HL-121697NIH HHS R01-HL-126543NIH HHS R01-HL-148094NIH HHS R01-HL-148094-01NIH HHS R35-HL-145241NIMH NIH HHS P30 MH116867
6 · The paper itself

Abstract

HIV infection is known to increase the risk for cardiovascular disease (CVD). Although almost 400 single-nucleotide polymorphisms (SNPs) are significantly associated with CAD alone, a subtype of CVD, the functions of most of these risk loci are unclear. Here, we investigated the impact of genetic variants/SNPs on the expression of nearby genes as potential cis expression quantitative trait loci (cis-eQTLs). We investigated peripheral blood mononuclear cells (PBMCs) from 31 participants in the Women's Interagency HIV Study (WIHS) using genotyping, single-cell (sc)RNA-seq, and CITE-seq. We found 187 statistically significant sc-eQTLs (single-cell eQTLs). In total, 160 were specific for just one immune cell type. We found a set of 3 sc-eQTLs impacting expression of IFNGR1 in CD4+ T cells at the mRNA and protein level as detected by flow cytometry. Two other sc-eQTLs representing one locus impact IFNG expression in CD8+ T cells, one of the primary sources of this cytokine. The sc-eQTLs impacting IFNG were associated with Th1 (T-helper1) gene expression patterns in CD4+ T cells in this cohort. These data suggest that some individuals are genetically predisposed to greater levels of Th1 polarization, which is known to be associated with atherosclerosis.

Indexed as

Cardiovascular DiseasesInterferon-gammaPolymorphism, Single NucleotideReceptors, InterferonAdultCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleGenetic Predisposition to DiseaseHIV InfectionsHumansInterferon gamma ReceptorLeukocytes, MononuclearMiddle AgedQuantitative Trait LociIFNG protein, humanInterferon-gammaInterferon gamma ReceptorReceptors, InterferonCVD (cardiovascular disease)IFNG (interferon-gamma)IFNGR1 (interferon-gamma receptor 1)PBMCs (peripheral blood mononuclear cells)sc-eQTL (single-cell expression quantitative trait locus)SNPs (single-nucleotide polymorphisms)T cells

Identifiers

PMID41009374
PMCPMC12865476

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.