Amelioration of Post-traumatic Osteoarthritis by Iontophoretic Liposomal Strontium Ranelate Collaborated with Low-Intensity Pulsed Ultrasound in Rats.

Chung-Hwan Chen, Syu-Lun Lin, Shyh Ming Kuo, Jyh-Mirn Lai, Wen-Ling Shih, Po-Chih Shen, Yi-Wen Kuo, Han Hsiang Huang

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chung-Hwan ChenOrthopedic Research Center, Kaohsiung Medical University, Kaohsiung City 80708, Taiwan.ORCID 0000-0001-8941-4792

Syu-Lun LinDepartment of Veterinary Medicine, National Chiayi University, Chiayi City 60054, Taiwan.

Shyh Ming KuoDepartment of Biomedical Engineering, I-Shou University, Kaohsiung City 82445, Taiwan.

Jyh-Mirn LaiDepartment of Veterinary Medicine, National Chiayi University, Chiayi City 60054, Taiwan.ORCID 0000-0003-2237-1526

Wen-Ling ShihDepartment of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan.

Po-Chih ShenDepartment of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City 80708, Taiwan.

Yi-Wen KuoOrthopedic Research Center, Kaohsiung Medical University, Kaohsiung City 80708, Taiwan.

Han Hsiang HuangDepartment of Veterinary Medicine, National Chiayi University, Chiayi City 60054, Taiwan.

Funding

Ministry of Science and Technology, Taiwan MOST 108-2313-B-415-005, MOST 109-2313-B-415-004

6 · The paper itself

Abstract

Osteoarthritis (OA), the most common form of arthritis, affects the whole synovial joint. Post-traumatic osteoarthritis (PTOA) is an important subtype of OA which develops after joint injury. The anti-PTOA effects of iontophoretic liposome-encapsulated strontium ranelate (L-SR) combined with low-intensity pulsed ultrasound (LIPUS) were examined by a culture of human OA chondrocytes (HOACs) in alginate beads and verified on an anterior cruciate ligament transection PTOA rat model. The aim of this study is to evaluate and establish an anti-PTOA therapy combined with L-SR, transdermal iontophoresis, and LIPUS. Treatment with 10

Indexed as

IontophoresisOsteoarthritisThiophenesUltrasonic TherapyUltrasonic WavesAnimalsChondrocytesDisease Models, AnimalGlycosaminoglycansHumansLiposomesMaleRatsRats, Sprague-DawleyGlycosaminoglycansLiposomesstrontium ranelateThiophenesliposome-encapsulated strontium ranelatelow-intensity pulsed ultrasoundposttraumatic osteoarthritis

Identifiers

PMID41009383

DOI10.3390/ijms26188815

PMCPMC12470037

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.