Evidence mapPaperPMID 41009424Full record

ReviewInternational journal of molecular sciences2025

The Role of Skin Microbiota in Facial Dermatoses and Related Factors: A Narrative Review.

Iva Ferček, Petar Ozretić, Lucija Zanze, Zoran Zoričić, Lorena Dolački, Rok Čivljak, Liborija Lugović-Mihić

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Iva FerčekDepartment of Ophthalmology, Zabok General Hospital and Croatian Veterans' Hospital, 49210 Zabok, Croatia.
Petar OzretićLaboratory for Hereditary Cancer, Division of Molecular Medicine, Ruđer Bošković Institute, 10000 Zagreb, Croatia.ORCID 0000-0001-9757-6636
Lucija ZanzeFamily Physician Office, 10000 Zagreb, Croatia.
Zoran ZoričićDepartment of Psychiatry, University Hospital Center Sestre Milosrdnice, 10000 Zagreb, Croatia.
Lorena DolačkiSchool of Dental Medicine, University of Zagreb, 10000 Zagreb, Croatia.ORCID 0000-0001-6233-2391
Rok ČivljakDepartment for Respiratory Infections, University Hospital for Infectious Diseases "Dr. Fran Mihaljević", 10000 Zagreb, Croatia.ORCID 0000-0001-8766-7438
Liborija Lugović-MihićSchool of Dental Medicine, University of Zagreb, 10000 Zagreb, Croatia.ORCID 0000-0001-7494-5742

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory facial dermatoses (atopic dermatitis [AD], acne vulgaris, contact dermatitis, seborrheic dermatitis, rosacea, perioral dermatitis, and demodicosis, etc.) often profoundly impact patients' appearance and psychological well-being. In this narrative review, we wanted to present the current knowledge on the role of skin microbiota in common facial dermatoses. Skin keratinocytes are the primary producers of antimicrobial peptides (AMPs) and express Toll-like receptors (TLRs), which stimulate the T helper (Th1) immune response, with the production of interferon (IFN). They can also produce certain pro-inflammatory cytokines, namely IL-1β, IL-18, IL-6, IL-10, and the tumor necrosis factor (TNF). In healthy infants, the bacterial skin microbiota is predominantly composed of Firmicutes (genera

Indexed as

Facial DermatosesMicrobiotaSkinCytokinesHumansSkin MicrobiomeToll-Like ReceptorsCytokinesToll-Like Receptorsacne vulgarisatopic dermatitiscontact dermatitisfaceimmunologymicrobiomepsoriasisrosaceaseborrheic dermatitisskin microbiota

Identifiers

PMID41009424
PMCPMC12469492

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.