Environmental Insults to Glucose Metabolism: The Role of Pollutants in Insulin Resistance.

Insulin resistance is a condition of impaired tissue reactivity to insulin. This state is primarily associated with obesity and the lifestyle of modern Western societies, which favors abnormalities of glucose and lipid homeostasis. As a result, more and more people suffer from illnesses that develop because of the disturbed metabolic function of insulin, including type 2 diabetes, nonalcoholic fatty liver disease and polycystic ovarian syndrome. There are many studies describing the relationship between declining sensitivity to insulin and insufficient physical activity or unhealthy dietary habits. However, there is a vast number of other factors that may contribute to the development of this condition. In recent years, more attention has been paid to environmental pollutants as promoters of insulin resistance. As the overall grade of waste accumulation in the environment rises, factors like toxic metals, pesticides, dust, harmful gases and micro- or nanoplastics are starting to pose an increasingly serious threat in the context of metabolic disorder development. This review gathers data concerning the influence of the mentioned pollutants on the metabolic health of living organisms, with particular emphasis on the impact on carbohydrate processing, insulin resistance and molecular pathways associated with these processes.