Evidence map›Paper›PMID 41009650›Full record

ArticleInternational journal of molecular sciences2025

The Activity of Protectin DX, 17 HDHA and Leukotriene B4 Is Correlated with Interleukin-1β (IL-1β) and Interleukin-1 Receptor Antagonist (IL-1Ra) in the Early Subacute Phase of Stroke.

Dariusz Kotlega, Arleta Drozd, Agnieszka Zembron-Lacny, Barbara Morawin, Karina Ryterska, Malgorzata Szczuko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dariusz KotlegaDepartment of Pharmacology and Toxicology, University of Zielona Gora, 65-417 Zielona Gora, Poland.ORCID 0000-0002-3116-9656
Arleta DrozdDepartment of Applied Microbiology and Human Nutrition Physiology, Faculty of Food Sciences and Fisheries, West Pomeranian University of Technology, 70-310 Szczecin, Poland.ORCID 0000-0002-5816-2040
Agnieszka Zembron-LacnyFaculty of Medicine, University of Warsaw, 02-089 Warsaw, Poland.ORCID 0000-0001-7596-9850
Barbara MorawinDepartment of Applied and Clinical Physiology, University of Zielona Gora, 65-417 Zielona Gora, Poland.ORCID 0000-0002-5874-1886
Karina RyterskaDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland.ORCID 0000-0003-2791-3312
Malgorzata SzczukoDepartment of Bromatology and Nutritional Diagnostics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland.ORCID 0000-0001-9808-0624

Funding

Minister of Science and Higher Education, Poland 002/RID/2018/19
6 · The paper itself

Abstract

Ischemic stroke is a leading cause of mortality and disability in adults. The inflammatory cascade is driven by various inflammatory molecules, such as interleukin-1β (IL-1β), and counteracted by its antagonist, interleukin-1 receptor antagonist (IL-1Ra). Eicosanoids are inflammatory derivatives of free fatty acids. Arachidonic acid (AA) derivatives exhibit pro-inflammatory activity, while eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) derivatives, known as specialized pro-resolving mediators, have anti-inflammatory properties. This study aimed to analyze potential associations between eicosanoids and key inflammatory molecules, including IL-1β and its antagonist IL-1Ra. In this prospective study, we investigated inflammatory molecules in 73 ischemic stroke patients. We analyzed interactions between IL-1β, IL-1Ra, and eicosanoids as follows: resolvin E1, prostaglandin E2, resolvin D1, lipoxin A4 (5S, 6R, 15R), protectin DX, maresin 1, leukotriene B4, 18RS-HEPE, 13S-HODE, 9S-HODE, 15S-HETE, 17 HDHA, 12S-HETE, 5-oxo-ETE, and 5-HETE. In 73 ischemic stroke patients, mean IL-1β was 1.31 ± 1.54 pg/mL and IL-1Ra 810.8 ± 691.0 pg/mL. Spearman correlations showed positive associations between IL-1β and protectin DX (ρ = 0.56,

Indexed as

Docosahexaenoic AcidsInterleukin-1betaInterleukin 1 Receptor Antagonist ProteinIschemic StrokeLeukotriene B4StrokeAgedAged, 80 and overFemaleHumansMaleMiddle AgedProspective Studies17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acidDocosahexaenoic AcidsIL1B protein, humanIL1RN protein, humanInterleukin-1betaInterleukin 1 Receptor Antagonist ProteinLeukotriene B4protectin D1eicosanoidsinflammationinterleukin-1 beta (IL-1β)interleukin-1 receptor antagonist (IL-1Ra)ischaemic strokeneuroinflammation

Identifiers

PMID41009650
PMCPMC12471189

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.