Evidence map›Paper›PMID 41009672›Full record

ArticleInternational journal of molecular sciences2025

Efficacy of 2,4-Dinitrobenzenesulfonic Acid (DNBS) in the Maintenance of a Model of Inflammatory Bowel Disease in Pigs (

Dominika Szkopek, Jarosław Woliński, Łukasz Kopiasz, Katarzyna Dziendzikowska, Kamil Zaworski, Rafał Sapierzyński, Joanna Gromadzka-Ostrowska

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dominika SzkopekLaboratory of Large Animal Models, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland.ORCID 0000-0001-5898-3909
Jarosław WolińskiLaboratory of Large Animal Models, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland.ORCID 0000-0001-8645-1045
Łukasz KopiaszDepartment of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-776 Warsaw, Poland.ORCID 0000-0002-7474-952X
Katarzyna DziendzikowskaDepartment of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-776 Warsaw, Poland.ORCID 0000-0002-8069-6356
Kamil ZaworskiDepartment of Animal Physiology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland.ORCID 0000-0003-4538-3159
Rafał SapierzyńskiDepartment of Pathology and Veterinary Diagnostics, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159, 02-776 Warsaw, Poland.ORCID 0000-0003-2111-5117
Joanna Gromadzka-OstrowskaDepartment of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-776 Warsaw, Poland.ORCID 0000-0002-9529-3744

Funding

National Science Centre 2022/47/B/NZ9/03123
6 · The paper itself

Abstract

Inflammatory bowel diseases (IBD), such as Crohn's disease (CD) and ulcerative colitis (UC), are chronic, progressive conditions with increasing prevalence worldwide. The aim of this study was to evaluate the usefulness of a porcine model of colitis induced by 2,4-dinitrobenzenesulfonic acid (DNBS) as a translational model of IBD. Sixteen Polish White pigs were divided into a control group and colitis group. Colitis was induced by rectal administration of DNBS (80 mg/kg in 50% ethanol). Clinical status, hematological and biochemical parameters, fecal calprotectin levels, cytokine plasma concentrations, and histopathological changes in the gastrointestinal tract were evaluated. DNBS administration resulted in persistent diarrhea and mild abdominal pain without general deterioration of health. Significant increases in fecal calprotectin levels and aspartate aminotransferase (AST) activity were observed. Histopathological changes in the colon were limited to the mucosa, which is similar to human UC, while the mild changes observed in the ileum indicate similarity to CD. This model is characterized by moderate inflammation, high reproducibility, and low mortality, making it valuable model in translational research on IBD.

Indexed as

BenzenesulfonatesInflammatory Bowel DiseasesAnimalsColonCytokinesDinitrofluorobenzeneDisease Models, AnimalFecesSus scrofaSwine2,4-dinitrofluorobenzene sulfonic acidBenzenesulfonatesCytokinesDinitrofluorobenzeneCrohn’s diseaseDNBSinflammatory bowel diseasepigsporcine colitis modelulcerative colitis

Identifiers

PMID41009672
PMCPMC12470971

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.