Evidence map›Paper›PMID 41009674›Full record

ArticleInternational journal of molecular sciences2025

Protective Effects of Methanolic Extract of

Elisaveta Apostolova, Kristina Stavrakeva, Vesela Kokova, Ivica Dimov, Mariya Choneva, Delyan Delev, Ilia Kostadinov, Ilia Bivolarski, Maria Koleva, Rumen Mladenov and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Methanolic Extract ofCurrent issues in molecular biology · 2026
    Article
  2. Article
  3. Article
  4. Nephroprotective Effect of Methanolic Extract ofInternational journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Elisaveta ApostolovaDepartment of Pharmacology, Toxicology, and Pharmacotherapy, Faculty of Pharmacy, Medical University of Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria.ORCID 0000-0002-5167-3278
Kristina StavrakevaDepartment of Pharmacology, Toxicology, and Pharmacotherapy, Faculty of Pharmacy, Medical University of Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria.ORCID 0009-0006-6640-8617
Vesela KokovaDepartment of Pharmacology, Toxicology, and Pharmacotherapy, Faculty of Pharmacy, Medical University of Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria.ORCID 0000-0002-5578-7862
Ivica DimovDepartment of Medical Biochemistry, Faculty of Pharmacy, Medical University of Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria.ORCID 0000-0002-8406-1446
Mariya ChonevaDepartment of Medical Biochemistry, Faculty of Pharmacy, Medical University of Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria.ORCID 0000-0002-5489-8106
Delyan DelevDepartment of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Medical University of Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria.ORCID 0000-0003-3695-5688
Ilia KostadinovResearch Institute, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.ORCID 0000-0002-2397-0988
Ilia BivolarskiDepartment of General and Clinical Pathology, Faculty of Medicine, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria.
Maria KolevaDepartment of General and Clinical Pathology, Faculty of Medicine, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria.
Rumen MladenovDepartment of Botany and Biological Education, Faculty of Biology, University of Plovdiv "Paisii Hilendarski", 24 Tsar Assen Str., 4000 Plovdiv, Bulgaria.
Plamen StoyanovDepartment of Botany and Biological Education, Faculty of Biology, University of Plovdiv "Paisii Hilendarski", 24 Tsar Assen Str., 4000 Plovdiv, Bulgaria.ORCID 0000-0002-5631-1444
Anelia BivolarskaDepartment of Medical Biochemistry, Faculty of Pharmacy, Medical University of Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria.ORCID 0000-0002-2157-3858

Funding

Medical University of Plovdiv NO-03/2023
6 · The paper itself

Abstract

Acetaminophen (APAP) overdose can result in potentially fatal acute liver failure, with free radical formation identified as a major mechanism of liver tissue damage.

Indexed as

AcetaminophenChemical and Drug Induced Liver InjuryPlant ExtractsProtective AgentsAlanine TransaminaseAnimalsAntioxidantsAspartate AminotransferasesLiverMaleMalondialdehydeMethanolOxidative StressRatsRats, WistarTumor Necrosis Factor-alphaAcetaminophenAlanine TransaminaseAntioxidantsAspartate AminotransferasesMalondialdehydeMethanolPlant ExtractsProtective AgentsTumor Necrosis Factor-alpha8-OH-dGALTanimal modelsASTbiochemical markershistopathological evaluationlinarinMDAparacetamol-induced hepatotoxicityrosmarinic acid

Identifiers

PMID41009674
PMCPMC12471278

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.