Evidence mapPaperPMID 41009677Full record

ArticleInternational journal of molecular sciences2025

In Vitro Assessment of Electrospun PVP+AgNPs Scaffolds for Bioactive Medical Use.

Ileana Ielo, Luana Vittoria Bauso, Antonio Laezza, Paola Campione, Luigi Fabiano, Martina Pastorello, Andreana Marino, Alessandro Laurita, Antonietta Pepe, Brigida Bochicchio and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ileana IeloDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences (ChiBioFarAm), University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0002-6101-8015
Luana Vittoria BausoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences (ChiBioFarAm), University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0001-5197-6570
Antonio LaezzaDepartment of Basic and Applied Sciences (DISBA), University of Basilicata, Via Ateneo Lucano 10, 85100 Potenza, Italy.ORCID 0000-0002-2058-9719
Paola CampioneDepartment of Chemical Sciences, University of Catania and CSGI, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0009-0004-1756-028X
Luigi FabianoDepartment of Chemical Sciences, University of Catania and CSGI, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0009-0001-5721-4048
Martina PastorelloDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences (ChiBioFarAm), University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.ORCID 0009-0008-9652-1172
Andreana MarinoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences (ChiBioFarAm), University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0001-8751-8811
Alessandro LauritaDepartment of Basic and Applied Sciences (DISBA), University of Basilicata, Via Ateneo Lucano 10, 85100 Potenza, Italy.ORCID 0000-0001-8214-3811
Antonietta PepeDepartment of Basic and Applied Sciences (DISBA), University of Basilicata, Via Ateneo Lucano 10, 85100 Potenza, Italy.ORCID 0000-0002-1285-2273
Brigida BochicchioDepartment of Basic and Applied Sciences (DISBA), University of Basilicata, Via Ateneo Lucano 10, 85100 Potenza, Italy.ORCID 0000-0002-0700-9257
Giovanna De LucaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences (ChiBioFarAm), University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0002-5115-7572
Grazia Maria Lucia MessinaDepartment of Chemical Sciences, University of Catania and CSGI, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0001-6144-4914
Giovanna CalabreseDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences (ChiBioFarAm), University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0003-1937-5403

Funding

Rome Technopole -PNRR Mission 4, Component 2, Investment 1.5, funded by the European Un-ion-NextGenerationEU. Project BEST-DRESS - Biomimetic Electrospun Scaffold as susTainable wound DRESSing device, CUP F33C24000360006
6 · The paper itself

Abstract

Chronic wounds and post-operative complications generate significant biomedical challenges due to impaired tissue regeneration and persistent microbial infections, often aggravated by biofilm formation and antibiotic resistance. To address these issues, this study investigates the development and in vitro evaluation of electrospun polyvinylpyrrolidone (PVP) scaffolds embedded with silver nanoparticles (AgNPs), designed as multifunctional bioactive platforms for wound healing and implant applications. AgNPs were synthesized and uniformly incorporated into the PVP matrix using optimized electrospinning parameters, harnessing their antimicrobial and anti-inflammatory properties alongside the hydrophilicity, biocompatibility, and chemical stability of PVP. Structural and mechanical characterization, including Transmission Electron Microscopy (TEM) and Atomic Force Microscopy (AFM), homogenous nanoparticle dispersion, and favorable mechanical properties, such as Young's modulus. In vitro cytotoxicity assays with fibroblast cell lines demonstrated good biocompatibility, while antibiofilm activity against

Indexed as

Metal NanoparticlesPovidoneSilverTissue ScaffoldsAnimalsAnti-Bacterial AgentsBiocompatible MaterialsBiofilmsCell LineFibroblastsHumansMiceStaphylococcus aureusWound HealingAnti-Bacterial AgentsBiocompatible MaterialsPovidoneSilverantibiofilm activitybioactive scaffoldsbiocompatibilityelectrospun scaffoldssilver nanoparticles

Identifiers

PMID41009677
PMCPMC12470899

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.