Evidence map›Paper›PMID 41009687›Full record

ArticleInternational journal of molecular sciences2025

SERCA Silencing Alleviates Aß

Elena Caldero-Escudero, Silvia Romero-Sanz, Pilar Álvarez-Illera, Silvia Fernandez-Martinez, Sergio De la Fuente, Paloma García-Casas, Rosalba I Fonteriz, Mayte Montero, Javier Alvarez, Jaime Santo-Domingo

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elena Caldero-EscuderoDepartment de Biochemistry, Molecular Biology and Physiology, Faculty of Medicine, University of Valladolid (UVA), Ramón y Cajal, 7, E-47005 Valladolid, Spain.ORCID 0009-0000-0694-3243
Silvia Romero-SanzDepartment de Biochemistry, Molecular Biology and Physiology, Faculty of Medicine, University of Valladolid (UVA), Ramón y Cajal, 7, E-47005 Valladolid, Spain.ORCID 0000-0003-4671-7376
Pilar Álvarez-IlleraDepartment de Biochemistry, Molecular Biology and Physiology, Faculty of Medicine, University of Valladolid (UVA), Ramón y Cajal, 7, E-47005 Valladolid, Spain.
Silvia Fernandez-MartinezInstitute of Biomedicine and Molecular Genetics (IBGM), Higher Council for Scientific Research (CSIC)-University of Valladolid (UVA), Sanz y Fores, 3, E-47003 Valladolid, Spain.
Sergio De la FuenteDepartment de Biochemistry, Molecular Biology and Physiology, Faculty of Medicine, University of Valladolid (UVA), Ramón y Cajal, 7, E-47005 Valladolid, Spain.
Paloma García-CasasDepartment de Biochemistry, Molecular Biology and Physiology, Faculty of Medicine, University of Valladolid (UVA), Ramón y Cajal, 7, E-47005 Valladolid, Spain.
Rosalba I FonterizDepartment de Biochemistry, Molecular Biology and Physiology, Faculty of Medicine, University of Valladolid (UVA), Ramón y Cajal, 7, E-47005 Valladolid, Spain.ORCID 0000-0001-8349-6264
Mayte MonteroDepartment de Biochemistry, Molecular Biology and Physiology, Faculty of Medicine, University of Valladolid (UVA), Ramón y Cajal, 7, E-47005 Valladolid, Spain.
Javier AlvarezDepartment de Biochemistry, Molecular Biology and Physiology, Faculty of Medicine, University of Valladolid (UVA), Ramón y Cajal, 7, E-47005 Valladolid, Spain.ORCID 0000-0003-0636-5521
Jaime Santo-DomingoDepartment de Biochemistry, Molecular Biology and Physiology, Faculty of Medicine, University of Valladolid (UVA), Ramón y Cajal, 7, E-47005 Valladolid, Spain.ORCID 0000-0001-5501-0482

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Sarco Endoplasmic Reticulum Ca

Indexed as

Amyloid beta-PeptidesCaenorhabditis elegansCaenorhabditis elegans ProteinsPeptide FragmentsSarcoplasmic Reticulum Calcium-Transporting ATPasesAlzheimer DiseaseAnimalsCalciumDisease Models, AnimalEndoplasmic ReticulumGene SilencingHumansMitochondriaReactive Oxygen SpeciesAmyloid beta-Peptidesamyloid beta-protein (1-42)Caenorhabditis elegans ProteinsCalciumPeptide FragmentsReactive Oxygen SpeciesSarcoplasmic Reticulum Calcium-Transporting ATPasesAlzheimer’s diseasebeta-amyloidC. elegansER Ca2+ signalingmitochondriasca-1SERCA

Identifiers

PMID41009687
PMCPMC12470765

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.