Evidence map›Paper›PMID 41009739›Full record

ArticleInternational journal of molecular sciences2025

ALH Inhibition as a Molecular Initiating Event in the Adverse Outcome Pathway of Benomyl Toxicity in

Lucía Eugenia Fernandez-Hubeid, Romina Deza-Ponzio, Paula Alejandra Albrecht, Verónica Leonor Romero, Candelaria Gonzales-Moreno, Melisa Rut Ferreyra, Yanina Soledad Moran, Miriam Beatriz Virgolini

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lucía Eugenia Fernandez-HubeidDepartamento de Farmacología Otto Orsingher, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba X5000HUA, Argentina.
Romina Deza-PonzioDepartamento de Farmacología Otto Orsingher, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba X5000HUA, Argentina.
Paula Alejandra AlbrechtDepartamento de Farmacología Otto Orsingher, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba X5000HUA, Argentina.
Verónica Leonor RomeroDepartamento de Farmacología Otto Orsingher, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba X5000HUA, Argentina.ORCID 0000-0003-0867-4280
Candelaria Gonzales-MorenoDepartamento de Farmacología Otto Orsingher, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba X5000HUA, Argentina.
Melisa Rut FerreyraDepartamento de Farmacología Otto Orsingher, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba X5000HUA, Argentina.
Yanina Soledad MoranDepartamento de Farmacología Otto Orsingher, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba X5000HUA, Argentina.ORCID 0000-0002-1393-4190
Miriam Beatriz VirgoliniDepartamento de Farmacología Otto Orsingher, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba X5000HUA, Argentina.ORCID 0000-0002-0784-2468

Funding

Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación BID PICT 2019-02444
6 · The paper itself

Abstract

Dithiocarbamate fungicides, including benomyl (methyl 1-butylcarbamoyl-2-benzimidazolecarbamate), share a common mechanism of toxicity by inhibiting aldehyde dehydrogenases (ALDHs), enzymes essential for detoxifying reactive aldehydes. One such aldehyde, 3,4-dihydroxyphenylacetaldehyde (DOPAL), a dopamine metabolite, is implicated in the catecholaldehyde hypothesis of Parkinson's disease. This study examines ALDH inhibition as the molecular initiating event (MIE) within an adverse outcome pathway (AOP) leading to neurotoxicity.

Indexed as

Aldehyde DehydrogenaseCaenorhabditis elegansCaenorhabditis elegans ProteinsFungicides, IndustrialParkinsonian Disorders3,4-Dihydroxyphenylacetic AcidAnimalsDopaminergic NeuronsLipid PeroxidationOxidative Stress3,4-dihydroxyphenylacetaldehyde3,4-Dihydroxyphenylacetic AcidAldehyde DehydrogenaseCaenorhabditis elegans ProteinsFungicides, IndustrialALDHbenomylCaenorhabditis elegansdopamineparkinsonism

Identifiers

PMID41009739
PMCPMC12471186

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.