Evidence mapPaperPMID 41009789Full record

ArticleInternational journal of molecular sciences2025

Inhibition of HCN Channels Enhances Oxidative Stress and Autophagy of NRK-52E Cells Under NH

Zinaeli López-González, Laura I Escobar, Daniel León-Aparicio, Abirán Fernando Mejía-Peralta, Teresa Padilla-Flores, Isabel Larre, Carolina Salvador, Omar Noel Medina-Campos, José Pedraza-Chaverri, Marisol de la Fuente-Granada

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zinaeli López-GonzálezDepartamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, Mexico.
Laura I EscobarDepartamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, Mexico.
Daniel León-AparicioDepartamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, Mexico.
Abirán Fernando Mejía-PeraltaDepartamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, Mexico.ORCID 0009-0007-8554-9076
Teresa Padilla-FloresDepartamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, Mexico.
Isabel LarreDepartamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, Mexico.ORCID 0000-0003-0768-3556
Carolina SalvadorDepartamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, Mexico.
Omar Noel Medina-CamposDepartamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, Mexico.ORCID 0000-0001-8264-0412
José Pedraza-ChaverriDepartamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, Mexico.ORCID 0000-0001-6628-4411
Marisol de la Fuente-GranadaDepartamento Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, Mexico.ORCID 0000-0002-6878-4265

Funding

CONACYT 2023-2024-190CONACYT A1-S-8731Universidad Nacional Autónoma de México (PAPIIT-DGAPA) IN204123
6 · The paper itself

Abstract

The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the kidney participate in reabsorbing potassium (K

Indexed as

Ammonium ChlorideAutophagyHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsOxidative StressAnimalsCell LineKidney Tubules, ProximalLysosomesMembrane Potential, MitochondrialMitochondriaPyrimidinesRatsReactive Oxygen SpeciesAmmonium ChlorideHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsPyrimidinesReactive Oxygen SpeciesautophagyHCN3 lysosomal channelHCN3 mitochondrial channelHyperpolarization-activated cyclic nucleotide-gated cation (HCN) channelsoxidative stressZD7288

Identifiers

PMID41009789
PMCPMC12471236

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.