Synergistic Antimicrobial Activity of Vancomycin, Ceftriaxone, and Gentamicin Against

Mariana Neri Lucas Kurihara, Isabelle Frois Brasil, Mayara Muniz de Andrade Silva, Mauro Jose Salles

Abstract read

In one paragraph

Article in Antibiotics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mariana Neri Lucas KuriharaSpecial Laboratory of Clinical Microbiology (LEMC), Department of Medicine, Division of Infectious Diseases, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo 04024-002, Brazil.

Isabelle Frois BrasilSpecial Laboratory of Clinical Microbiology (LEMC), Department of Medicine, Division of Infectious Diseases, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo 04024-002, Brazil.ORCID 0009-0006-4899-1888

Mayara Muniz de Andrade SilvaSpecial Laboratory of Clinical Microbiology (LEMC), Department of Medicine, Division of Infectious Diseases, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo 04024-002, Brazil.

Mauro Jose SallesSpecial Laboratory of Clinical Microbiology (LEMC), Department of Medicine, Division of Infectious Diseases, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo 04024-002, Brazil.ORCID 0000-0002-5443-6024

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectives

methodsMinimum inhibitory concentrations (MICs) were determined using broth microdilution following BrCAST guidelines. Synergistic activity was assessed using the checkerboard assay and interpreted via fractional inhibitory concentration indices (FICIs). The in vivo efficacy of antibiotic combinations with bioactive glass S53P4 (BAG) was evaluated in the

resultsAll

conclusionsAcombination of a cephalosporin with an aminoglycoside, particularly when incorporated into a biomaterial matrix, enhances antimicrobial activity against both clinical and reference strains of

Indexed as

antibiotic synergybioactive glass S53P4Cutibacterium acnesGalleria mellonella modelorthopaedic implant-associated infection

Identifiers

PMID41009901

DOI10.3390/antibiotics14090923

PMCPMC12466660

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.