Evidence map›Paper›PMID 41010023›Full record

ArticleGenes2025

APOL1-Risk Genotype Induces Inflammatory and Hypoxic Gene Expression in Donor Kidneys.

Meghan Unes, Sree Kolli, Shaurya Mehta, Chandrashekhara Manithody, Jonathan Bruno, Krista L Lentine, Ajay Jain, Mustafa Nazzal, Yasar Caliskan

Abstract read
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Meghan UnesSchool of Medicine, Saint Louis University, 1402 S. Grand Blvd, St. Louis, MO 63104, USA.ORCID 0009-0007-7387-2212
Sree KolliSchool of Medicine, Saint Louis University, 1402 S. Grand Blvd, St. Louis, MO 63104, USA.
Shaurya MehtaDepartment of Pediatrics, School of Medicine, Saint Louis University, 1402 S. Grand Blvd, St. Louis, MO 63104, USA.
Chandrashekhara ManithodyDepartment of Pediatrics, School of Medicine, Saint Louis University, 1402 S. Grand Blvd, St. Louis, MO 63104, USA.
Jonathan BrunoDivision of Nephrology, SSM Health Saint Louis University Hospital, 1201 S. Grand Blvd, St. Louis, MO 63104, USA.
Krista L LentineDivision of Nephrology, SSM Health Saint Louis University Hospital, 1201 S. Grand Blvd, St. Louis, MO 63104, USA.ORCID 0000-0002-9423-4849
Ajay JainDepartment of Pediatrics, School of Medicine, Saint Louis University, 1402 S. Grand Blvd, St. Louis, MO 63104, USA.ORCID 0000-0002-9420-5722
Mustafa NazzalDepartment of Surgery, SSM Health Saint Louis University Hospital, 1201 S. Grand Blvd, St. Louis, MO 63104, USA.
Yasar CaliskanDivision of Nephrology, SSM Health Saint Louis University Hospital, 1201 S. Grand Blvd, St. Louis, MO 63104, USA.ORCID 0000-0003-3816-8047

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectives

methodsNon-utilized deceased donor kidney pairs from donors of African ancestry were procured from Mid-America Transplant after being deemed unsuitable for kidney transplant. Samples were collected from each donor kidney pair and DNA was extracted for

resultsDonor genotyping identified kidney pairs as heterozygous for the G1 RRV (G1/G0), homozygous for the G0 allele (G0/G0), and homozygous for the G2 RRV (G2/G2), respectively. All kidneys were successfully reperfused, with mRNA transcript levels of

conclusionDonor kidney pairs with the high-risk

Indexed as

Apolipoprotein L1HypoxiaInflammationKidneyKidney TransplantationAdultFemaleGene Expression RegulationGenotypeHumansMaleMiddle AgedOrgan PreservationPolymorphism, Single NucleotideTissue DonorsAPOL1 protein, humanApolipoprotein L1APOL1graft outcomeshypoxiaischemia and reperfusion injurykidney transplantationnephropathynormothermic machine perfusion

Identifiers

PMID41010023
PMCPMC12469248

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.