Evidence map›Paper›PMID 41010299›Full record

ReviewLife (Basel, Switzerland)2025

Primary Lymphoma of Peripheral Nerve: Rare or Misdiagnosed? A Systematic Review.

Ludovico Caruso, Adriano Cannella, Giulia Maria Sassara, Antonio Maria Rapisarda, Marco Passiatore, Giuseppe Rovere, Rocco De Vitis

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ludovico CarusoDepartment of Ageing, Neurosciences, Head-Neck and Orthopaedics Sciences, Hand Surgery Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, 00168 Rome, Italy.
Adriano CannellaDepartment of Ageing, Neurosciences, Head-Neck and Orthopaedics Sciences, Hand Surgery Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, 00168 Rome, Italy.ORCID 0000-0001-8163-562X
Giulia Maria SassaraDepartment of Ageing, Neurosciences, Head-Neck and Orthopaedics Sciences, Hand Surgery Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, 00168 Rome, Italy.ORCID 0000-0002-3003-2391
Antonio Maria RapisardaDepartment of Ageing, Neurosciences, Head-Neck and Orthopaedics Sciences, Hand Surgery Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, 00168 Rome, Italy.
Marco PassiatoreUnit of Orthopaedics, "Spedali Civili" Hospital, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-4361-6505
Giuseppe RovereDepartment of Clinical Science and Translational Medicine, Section of Orthopaedics and Traumatology, University of Rome "Tor Vergata", 00133 Rome, Italy.
Rocco De VitisDepartment of Ageing, Neurosciences, Head-Neck and Orthopaedics Sciences, Hand Surgery Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, 00168 Rome, Italy.ORCID 0000-0002-9714-1285

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrimary lymphoma of peripheral nerves (PLPN) is a rare extranodal non-Hodgkin lymphoma that mimics benign nerve conditions, leading to diagnostic delays. This systematic review evaluates the clinical, radiological, and pathological features of PLPN, alongside diagnostic and therapeutic strategies. MATERIALS AND

methodsA systematic search was conducted across PubMed, Scopus, and Web of Science, and identified 23 studies reporting 27 cases of PLPN. Data on demographics, clinical presentation, diagnostics, treatment, and outcomes were extracted and synthesized qualitatively due to study heterogeneity.

resultsThe sciatic nerve was most involved (48.15%), followed by the ulnar (18.5%) and radial nerves (18.5%). The median age at diagnosis was 58 years, with symptoms including motor deficits (88.9%), sensory disturbances (74.1%), and pain (70.4%). B-cell lymphomas accounted for 81.5% of cases, predominantly diffuse large B-cell lymphoma. MRI findings were non-specific; however, diffusion-weighted imaging (DWI) showed diagnostic potential. Treatments included combination therapies (51.9%), chemotherapy (25.9%), and surgery. Complete remission was achieved in 70.8%, with a 2-year survival rate of 83.3%.

conclusionsPLPN is rare but likely underdiagnosed. Early recognition requires multidisciplinary collaboration, advanced imaging, and standardized protocols. Future research should focus on molecular characterization, diagnostic criteria, and treatment optimization to improve outcomes for this challenging condition.

Indexed as

peripheral nerveprimary lymphomatumors

Identifiers

PMID41010299
PMCPMC12470766

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.