Evidence map›Paper›PMID 41010305›Full record

ArticleLife (Basel, Switzerland)2025

Higher NLR Values Can Predict Gram-Negative Spontaneous Bacterial Peritonitis and a High In-Hospital Mortality Rate in Patients with Spontaneous Bacterial Peritonitis.

Sergiu Marian Cazacu, Ovidiu Mircea Zlatian, Dragos Ovidiu Alexandru, Elena Leocadia Plesea, Ioan Alexandru Vacariu, Mihai Cimpoeru, Ion Rogoveanu, Camelia Cristiana Bigea, Cristina Maria Marginean, Sevastita Iordache

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sergiu Marian CazacuGastroenterology Department, University of Medicine and Pharmacy Craiova, Petru Rares Street no 2-4, 200349 Craiova, Romania.ORCID 0000-0001-9623-7683
Ovidiu Mircea ZlatianMicrobiology Department, University of Medicine and Pharmacy Craiova, Petru Rares Street no 2-4, 200349 Craiova, Romania.ORCID 0000-0003-3510-3838
Dragos Ovidiu AlexandruStatistics Department, University of Medicine and Pharmacy Craiova, Petru Rares Street no 2-4, 200349 Craiova, Romania.ORCID 0000-0001-7578-8048
Elena Leocadia PleseaMicrobiology Department, University of Medicine and Pharmacy Craiova, Petru Rares Street no 2-4, 200349 Craiova, Romania.
Ioan Alexandru VacariuDoctoral School, University of Medicine and Pharmacy Craiova, Petru Rares Street no 2-4, 200349 Craiova, Romania.
Mihai CimpoeruResident Physician, Emergency Clinic Hospital Craiova, 200642 Craiova, Romania.
Ion RogoveanuGastroenterology Department, University of Medicine and Pharmacy Craiova, Petru Rares Street no 2-4, 200349 Craiova, Romania.
Camelia Cristiana BigeaDoctoral School, University of Medicine and Pharmacy Craiova, Petru Rares Street no 2-4, 200349 Craiova, Romania.ORCID 0009-0008-8003-1750
Cristina Maria MargineanInternal Medicine Department, University of Medicine and Pharmacy Craiova, Petru Rares Street no 2-4, 200349 Craiova, Romania.ORCID 0009-0002-9956-4318
Sevastita IordacheGastroenterology Department, University of Medicine and Pharmacy Craiova, Petru Rares Street no 2-4, 200349 Craiova, Romania.ORCID 0000-0002-6280-6136

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSpontaneous bacterial peritonitis (SBP) represents a significant complication of liver cirrhosis; Gram-positive bacteria (GPB) predominance was recently noted in some areas, with increased antibiotic resistance. Etiology and mortality prediction are important in culture-negative SBP and for empirical antibiotherapy before the arrival of culture results.

methodsA retrospective study was performed on patients with cirrhosis and ascites admitted between 2018 and 2024, divided into culture-positive SBP (Gram-positive and Gram-negative), culture-negative SBP, and non-infected ascites. The NLR (neutrophil-to-lymphocyte ratio) accuracy for the prediction of SBP and in-hospital mortality was estimated using ROC analysis.

resultsOverall, 45 culture-positive SBP, 28 culture-negative SBP, and 600 control ascites were diagnosed; Gram-positive SBP represented 60%; median NLR values were significantly higher in patients with Gram-negative compared with Gram-positive SBP (8.79 in Gram-negative versus 3.92 in Gram-positive SBP, AUC 0.752,

conclusionsHigher NLR values were associated with Gram-negative SBP etiology and with in-hospital mortality in all cirrhosis, in SBP, and especially in culture-positive and Gram-negative SBP cases. High NLR values can predict the Gram-negative etiology in patients with an ascitic neutrophil count above 250/mm

Indexed as

antibiotic susceptibilityGram-negative bacteriaGram-positive bacteriaspontaneous bacterial peritonitis

Identifiers

PMID41010305
PMCPMC12470773

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.