Evidence mapPaperPMID 41010368Full record

ReviewLife (Basel, Switzerland)2025

Arrhythmias in Rheumatoid Arthritis: A Call for a Multidisciplinary Team.

Veronica Ungurean, Diana Elena Costan, Monica Claudia Dobos, Anca Ouatu, Paula Cristina Morariu, Alexandru Florinel Oancea, Maria Mihaela Godun, Diana-Elena Floria, Dragos Traian Marcu, Genoveva Livia Baroi and 5 more

Abstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Veronica UngureanDepartment of Medical Sciences II, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0009-0002-8097-2573
Diana Elena CostanDepartment of Medical Sciences II, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Monica Claudia DobosDepartment of Medical Sciences II, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Anca OuatuDepartment of Medical Sciences I, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0001-8923-8194
Paula Cristina MorariuDepartment of Medical Sciences I, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0009-0006-5066-0690
Alexandru Florinel OanceaDepartment of Medical Sciences I, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0002-5249-4562
Maria Mihaela GodunDepartment of Medical Sciences I, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Diana-Elena FloriaDepartment of Medical Sciences I, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Dragos Traian MarcuDepartment of Medical Sciences I, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Genoveva Livia BaroiDepartment of Surgery, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Silviu Marcel StanciuDepartment of Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy, Central Military Emergency University Hospital, 010825 Bucharest, Romania.
Anton KnielingDiscipline of Forensic Medicine, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, 16 Universitatii Street, 700115 Iasi, Romania.
Daniela Maria TanaseDepartment of Medical Sciences I, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0002-7144-2506
Codrina AncutaDepartment of Medical Sciences II, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0002-1777-8121
Mariana FloriaDepartment of Medical Sciences I, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0002-9465-1503

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRheumatoid arthritis is the most prevalent systemic inflammatory disease, mainly affecting the synovial tissue of small and large joints, also associated with significant extra-articular manifestations. Throughout the progression of the disease, cardiac structures may be affected, including the conducting system, myocardium, endocardium, coronary arteries, and valves, potentially resulting in a higher incidence of cardiac arrhythmias.

methodsWe performed a narrative review of the most recent studies that highlight the epidemiology, pathophysiology, diagnosis, and management of arrhythmias occurring in patients with rheumatoid arthritis. Furthermore, we examined the impact of disease-modifying antirheumatic drugs (DMARDs)-including conventional synthetic (csDMARDs), biologic (bDMARDs), and targeted synthetic agents (tsDMARDs)-on cardiac electrophysiology.

resultsCardiac immune cells may influence arrhythmogenesis through non-canonical and inflammatory mechanisms by modifying myocardial tissue architecture or by interacting with cardiomyocytes, potentially altering their electrical function.

conclusionsThis review emphasizes the essential role of a multidisciplinary approach integrating rheumatology and cardiology expertise in the screening and management of arrhythmias in patients with rheumatoid arthritis.

Indexed as

arrhythmiasatrial fibrillationbDMARDscsDMARDsepidemiologyrheumatoid arthritistsDMARDsventricular ectopic beats

Identifiers

PMID41010368
PMCPMC12471337

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.