ReviewLife (Basel, Switzerland)2025
Effect of Different Exercise Modalities on Inflammatory Markers in Individuals with Depressive Disorder: A Systematic Review and Meta-Analysis.
Review in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Molecules of mood: the integrated molecular transducers of exercise's antidepressant effects.Molecular genetics and genomics : MGG · 2026Review
- YY1 Transcriptionally Activates USP19 to Mediate TRAF6 Deubiquitination to Promote Microglial Inflammation and M1 Polarization in Depression Development.Neurochemical research · 2026Article
- Distinct Biomarker Patterns Reveal Metabolic-Inflammatory Profiles Across Mental Disorders.Biomolecules · 2026Article
- Stratifying the Inflamed Endotype in Difficult-to-Treat Depression: A Roadmap from Biomarkers to Precision Immunopsychiatry.Clinical neuropsychiatry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundOne of the important mechanisms of depression is long-term high levels of inflammation. Exercise may help relieve depressive symptoms and is associated with anti-inflammatory effects. This research methodically assesses how various exercise modalities influence peripheral inflammatory markers in individuals with depression, so that more personalized and precise exercise schemes can be provided for people with depression to improve inflammation.
methodsRandomized controlled trials on depressive disorder, exercise, and inflammation published until May 2025 were screened in five databases. The Cochrane Risk of Bias tool (RoB2.0) was used to evaluate potential biases, with random effects meta-analyses gauging the impact of varying exercise regimens on peripheral inflammatory markers (CRP, IL-6 and TNF-α) involving exercise types, intensity, frequency, and length. Meta-regression analyses were employed to show the sources of heterogeneity and investigate potential moderator variables influencing CRP, IL-6, and TNF-α (PROSPERO CRD42024590612).
resultsA total of 13 unique studies with 1004 participants were included. Overall, exercise training could alleviate depressive symptoms (SMD = -0.59, 95%CI: [-0.86, -0.32], I
conclusionsExercise could alleviate depressive symptoms in individuals with depression. However, the influence of exercise length on TNF-α levels has conflicting conclusions because of inconsistent evidence and substantial heterogeneity. Future high-quality trials with standardized biomarker measurements and better control of confounding factors are essential to determine whether the antidepressant effects of exercise are mediated by inflammation.
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