Evidence map›Paper›PMID 41010550›Full record

ArticleNutrients2025

Early Oral Administration of D-Chiro-Inositol Reverses Hippocampal Insulin and Glutamate Signaling Deficits in the 3×Tg Humanized Mouse Model of Alzheimer's Disease.

Beatriz Pacheco-Sánchez, Julia Verheul-Campos, Antonio Vargas, Rubén Tovar, Miguel Rodríguez-Pozo, Juan A Navarro, Antonio J López-Gambero, Elena Baixeras, Pedro J Serrano-Castro, Juan Suárez and 3 more

Abstract read
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Beatriz Pacheco-SánchezGrupo de Neuropsicofarmacología, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Unidad Clínica de Neurología, 29010 Málaga, Spain.ORCID 0000-0003-3058-0635
Julia Verheul-CamposGrupo de Neuropsicofarmacología, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Unidad Clínica de Neurología, 29010 Málaga, Spain.
Antonio VargasGrupo de Neuropsicofarmacología, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Unidad Clínica de Neurología, 29010 Málaga, Spain.
Rubén TovarGrupo de Neuropsicofarmacología, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Unidad Clínica de Neurología, 29010 Málaga, Spain.
Miguel Rodríguez-PozoGrupo de Neuropsicofarmacología, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Unidad Clínica de Neurología, 29010 Málaga, Spain.ORCID 0009-0007-5276-6082
Juan A NavarroGrupo de Neuropsicofarmacología, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Unidad Clínica de Neurología, 29010 Málaga, Spain.ORCID 0000-0003-3089-0983
Antonio J López-GamberoGrupo de Neuropsicofarmacología, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Unidad Clínica de Neurología, 29010 Málaga, Spain.ORCID 0000-0001-7716-9056
Elena BaixerasDepartamento de Bioquímica, Biología Molecular e Inmunología, Facultad de Medicina, Universidad de Málaga, 29010 Málaga, Spain.ORCID 0000-0001-6955-2434
Pedro J Serrano-CastroGrupo de Neuropsicofarmacología, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Unidad Clínica de Neurología, 29010 Málaga, Spain.
Juan SuárezGrupo de Neuropsicofarmacología, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Unidad Clínica de Neurología, 29010 Málaga, Spain.ORCID 0000-0001-5254-9802
Carlos SanjuanEuronutra S.L., Calle Johannes Kepler, 3, 29590 Málaga, Spain.ORCID 0000-0003-3505-0481
Patricia RiveraGrupo de Neuropsicofarmacología, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Unidad Clínica de Neurología, 29010 Málaga, Spain.ORCID 0000-0002-0478-6667
Fernando Rodríguez de FonsecaGrupo de Neuropsicofarmacología, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Unidad Clínica de Neurología, 29010 Málaga, Spain.ORCID 0000-0002-4516-5795

Funding

Instituto de Salud Carlos III. Proyectos de desarrollo tecnológico DTS22/00021Instituto de Salud Carlos III. Proyectos de Investigación en Salud PI22/00427
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer DiseaseGlutamic AcidHippocampusInsulinSignal TransductionAdministration, OralAnimalsDisease Models, AnimalFemaleHumansMaleMiceMice, TransgenicGlutamic AcidInsulin3×Tg-AD mouse modelAlzheimer’s diseasebrain insulin resistanceD-chiro-inositolglutamate receptorshippocampusproteomics

Identifiers

PMID41010550
PMCPMC12472782

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.