Evidence map›Paper›PMID 41011313›Full record

ArticleMicroorganisms2025

Deciphering Bacterial Community Succession and Pathogen Dynamics in ICU Ventilator Circuits Through Full-Length 16S rRNA Sequencing for Mitigating the Risk of Nosocomial Infections.

Hsin-Chi Tsai, Jung-Sheng Chen, Gwo-Jong Hsu, Bashir Hussain, I-Ching Lin, Tsui-Kang Hsu, Jing Han, Shih-Wei Huang, Chin-Chia Wu, Bing-Mu Hsu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hsin-Chi TsaiDepartment of Psychiatry, School of Medicine, Tzu Chi University, No. 701, Section 3, Zhongyang Rd., Hualien 970, Taiwan.
Jung-Sheng ChenDepartment of Medical Research, E-Da Hospital, I-Shou University, No. 1, Section 1, Xuecheng Rd., Kaohsiung 824, Taiwan.ORCID 0000-0003-3187-9479
Gwo-Jong HsuDivision of Infectious Disease, Department of Internal Medicine, Chia-Yi Christian Hospital, No. 539, Zhongxiao Rd., Chiayi 600, Taiwan.
Bashir HussainDepartment of Earth and Environmental Sciences, National Chung Cheng University, No. 168, Section 1, Daxue Rd., Chiayi 600, Taiwan.ORCID 0000-0003-4881-7872
I-Ching LinDepartment of Family Medicine, Asia University Hospital, No. 222, Fuxin Rd., Taichung 413, Taiwan.ORCID 0000-0002-1418-4977
Tsui-Kang HsuDepartment of Ophthalmology, Cheng Hsin General Hospital, No. 45, Zhenxing St., Taipei 112, Taiwan.
Jing HanDepartment of Rehabilitation, Ditmanson Medical Foundation, Chia-Yi Christian Hospital, No. 539, Zhongxiao Rd., Chiayi 600, Taiwan.
Shih-Wei HuangCenter for Environmental Toxin and Emerging Contaminant, Cheng Shiu University, No. 840, Chengqing Rd., Kaohsiung 824, Taiwan.ORCID 0000-0002-2410-5320
Chin-Chia WuDivision of Colorectal Surgery, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 2, Minsheng Rd., Chiayi 600, Taiwan.ORCID 0000-0002-6499-1072
Bing-Mu HsuDepartment of Earth and Environmental Sciences, National Chung Cheng University, No. 168, Section 1, Daxue Rd., Chiayi 600, Taiwan.ORCID 0000-0002-2988-8408

Funding

This research was supported by the National Science and Technology Council, Taiwan (NSTC 111-2116-M-194-010), Hualien Tzu-Chi General Hospital, Dalin Tzu-Chi Hospital, and Ditmanson Medical Foundation Chiayi Christian Hospital-National Chung Cheng Univers (NSTC 111-2116-M-194-010), (CYCH-CCU-2022-033).
6 · The paper itself

Abstract

The rapid evolution of ventilators and their circuits, coupled with varying maximum usage durations set by different hospitals globally, poses a significant risk for the proliferation and transmission of nosocomial infections in intensive care settings. This study investigated temporal changes in bacterial community structure and predicted metabolic functions in ventilator circuits over a three-week period, with a specific focus on ESKAPE pathogens. The results of full-length 16S rRNA sequencing revealed dynamic shifts in bacterial communities, with an increased bacterial diversity and unique species prevalence in week-2 compared to week-1 and week-3. However, a marked emergence of pathogenic bacteria, including

Indexed as

ESKAPE pathogenfull-length 16S rRNA genesnosocomial infectionventilator associated-pneumoniaventilator circuit

Identifiers

PMID41011313
PMCPMC12471920

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.