Evidence map›Paper›PMID 41011393›Full record

ArticleMicroorganisms2025

Changes in Probiotic Lachnospiraceae Genera Across Different Stages of COVID-19: A Meta-Analysis of 16S rRNA Microbial Data.

Clarissa Reginato Taufer, Juliana da Silva, Pabulo Henrique Rampelotto

Abstract read
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Clarissa Reginato TauferGraduate Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul, Porto Alegre 91501-970, Brazil.
Juliana da SilvaGraduate Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul, Porto Alegre 91501-970, Brazil.ORCID 0000-0002-1089-6766
Pabulo Henrique RampelottoBioinformatics and Biostatistics Core Facility, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 91501-970, Brazil.ORCID 0000-0002-8992-9697

Funding

CAPES 88887.513461/2020-00CAPES No. 88887.798411/2022-00
6 · The paper itself

Abstract

The gut microbiome has emerged as a potential modulator of COVID-19 severity, and there is particular interest in the Lachnospiraceae family due to its role in maintaining gut homeostasis. This study presents a comprehensive meta-analysis of microbiome datasets from multiple investigations focused on gut microbiota across various stages of COVID-19. We used a standardized bioinformatics pipeline based on Mothur v.1.47.0 and the SILVA v.138 reference database to analyze 16S rRNA gene sequencing data targeting the V3-V4 regions. Our findings reveal consistent patterns of depletion in key Lachnospiraceae genera, particularly

Indexed as

COVID-19disease severitygut microbiotaLachnospiraceaemicrobiome

Identifiers

PMID41011393
PMCPMC12471913

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.