Evidence map›Paper›PMID 41012406›Full record

ArticleToxics2025

Chronic Occupational Exposure to Chemical Mixtures Induces Genomic Instability in Paint Workers.

Servet Birgin İritaş, Merve Güdül Bacanlı, Gökçe Taner, Vugar Ali Türksoy, Lütfiye Tutkun, Ömer Hınç Yilmaz, Ayşe Nurşen Başaran

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Servet Birgin İritaşDepartment of Forensic Medicine, Faculty of Medicine, Ankara Yıldırım Beyazıt University, 06800 Ankara, Türkiye.ORCID 0000-0001-5283-9973
Merve Güdül BacanlıDepartment of Pharmaceutical Toxicology, Faculty of Pharmacy, Health Sciences University, 06018 Ankara, Türkiye.ORCID 0000-0001-8757-0572
Gökçe TanerDepartment of Bioengineering, Faculty of Engineering and Natural Sciences, Bursa Technical University, 16310 Bursa, Türkiye.ORCID 0000-0002-0290-1166
Vugar Ali TürksoyDepartment of Public Health, Faculty of Medicine, Yozgat Bozok University, 66100 Yozgat, Türkiye.
Lütfiye TutkunThe Association of Industrial Toxicology and Occupational Hygiene, 06660 Ankara, Türkiye.
Ömer Hınç YilmazDepartment of Public Health, Faculty of Medicine, Ankara Yıldırım Beyazıt University, 06800 Ankara, Türkiye.
Ayşe Nurşen BaşaranDepartment of Pharmaceutical Toxicology, Faculty of Pharmacy, Başkent University, 06800 Ankara, Türkiye.ORCID 0000-0001-8581-8933

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study's objective was to evaluate genotoxic effects on automotive paint workers who are exposed to a complex mixture of VOCs, heavy metals, and solvents. Biological samples, including blood, urine, and buccal epithelial cells, were collected from 80 exposed workers and 80 demographically matched control subjects. DNA damage was assessed using the alkaline COMET assay in lymphocytes and whole blood. The Buccal Micronucleus Cytome (BMCyt) assay was also employed to identify cytogenetic abnormalities. Additionally, trichloroacetic acid (TCA), hippuric acid (HA), phenol, and lead (Pb) levels were measured as biomarkers of exposure. A significant increase in DNA damage was observed in the lymphocytes and whole blood of exposed workers (

Indexed as

buccal micronucleus assaycomet assayDNA damagehippuric acidleadoccupational exposurepaint workersphenoltrichloroacetic acid

Identifiers

PMID41012406
PMCPMC12474480

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.