Evidence map›Paper›PMID 41012760›Full record

ArticleVeterinary sciences2025

Proinflammatory Cytokines, Type I Interferons, and Specialized Proresolving Mediators Hallmark the Influence of Vaccination and Marketing on Backgrounded Beef Cattle.

Hudson R McAllister, Sarah F Capik, Kelsey M Harvey, Bradly I Ramirez, Robert J Valeris-Chacin, Amelia R Woolums, Brandi B Karisch, Paul S Morley, Matthew A Scott

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hudson R McAllisterVeterinary Education, Research, and Outreach Program, Texas A&M University, Canyon, TX 79015, USA.ORCID 0000-0002-3015-2449
Sarah F CapikTumbleweed Veterinary Services, PLLC, Amarillo, TX 79118, USA.ORCID 0000-0002-3687-2279
Kelsey M HarveyPrairie Research Unit, Mississippi State University, Prairie, MS 39756, USA.
Bradly I RamirezVeterinary Education, Research, and Outreach Program, Texas A&M University, Canyon, TX 79015, USA.
Robert J Valeris-ChacinVeterinary Education, Research, and Outreach Program, Texas A&M University, Canyon, TX 79015, USA.
Amelia R WoolumsDepartment of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA.
Brandi B KarischDepartment of Animal and Dairy Sciences, Mississippi State University, Mississippi State, MS 39762, USA.ORCID 0000-0002-9805-4626
Paul S MorleyVeterinary Education, Research, and Outreach Program, Texas A&M University, Canyon, TX 79015, USA.ORCID 0000-0001-8138-2714
Matthew A ScottVeterinary Education, Research, and Outreach Program, Texas A&M University, Canyon, TX 79015, USA.ORCID 0000-0001-5243-7181

Funding

Texas A&M University System internal fundsUSDA NIFA AFRI 2019-67015-29845 and 2023-67015-39711
6 · The paper itself

Abstract

Cattle marketed through auction market systems and/or that remain unvaccinated are considered higher risk for BRD, but impacts on host response remain unclear. We sought to identify specific genomic patterns of beef calves vaccinated against BRD viruses or not and commercially marketed or directly transported in a split-plot randomized controlled trial. Forty-one calves who remained clinically healthy from birth through backgrounding were selected (randomly stratified) from a larger cohort of cattle (n = 81). Treatment groups included VAX/DIRECT (n = 12), VAX/AUCTION (n = 11), NOVAX/DIRECT (n = 7), and NOVAX/AUCTION (n = 11). Blood RNA was acquired across five time points, sequenced, and bioinformatically processed via HISAT2 and StringTie2. Significant transcriptional changes (FDR < 0.05) were observed at backgrounding entry (T5) in NOVAX/AUCTION cattle exhibiting 2809 uniquely differentially expressed genes and relative activation of immune, inflammatory, and metabolic pathways with upregulation of interferon-stimulated genes (e.g.,

Indexed as

bovine respiratory diseasecattleinflammationmarketingRNAtranscriptomicsvaccine

Identifiers

PMID41012760
PMCPMC12474404

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.