Evidence map›Paper›PMID 41012793›Full record

ArticleVeterinary sciences2025

Sheep Pox Susceptibility: Role of Genetic Variants, Gene Expression, and Immune-Oxidative Markers.

Asmaa A Darwish, Huda A Alqahtani, Amin Tahoun, Ahmed Ateya, Noha A Helmy, Amani A Hafez, Hanan M Alharbi, Khairiah M Alwutayd, Manal A Babaker, Ammar Al-Farga and 4 more

Abstract read
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In one paragraph

Article in Veterinary sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Asmaa A DarwishDepartment of Animal Health and Poultry, Animal and Poultry Production Division, Desert Research Center (DRC), Cairo 11753, Egypt.
Huda A AlqahtaniDepartment of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Amin TahounDepartment of Animal Medicine, Faculty of Veterinary Medicine, Kafrelshkh University, Kafrelsheikh 33516, Egypt.
Ahmed AteyaDepartment of Development of Animal Wealth, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.
Noha A HelmyVeterinary Serum and Vaccine Research Institute, Abbasia, Cairo 11566, Egypt.
Amani A HafezDepartment of Animal Health and Poultry, Animal and Poultry Production Division, Desert Research Center (DRC), Cairo 11753, Egypt.
Hanan M AlharbiDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.ORCID 0000-0003-2810-965X
Khairiah M AlwutaydDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.ORCID 0000-0001-7071-8710
Manal A BabakerDepartment of Chemistry, Faculty of Science, Majmaah University, Al Majmaah 11952, Saudi Arabia.
Ammar Al-FargaDepartment of Biological Sciences, College of Science, University of Jeddah, Jeddah 22233, Saudi Arabia.ORCID 0000-0002-0233-5539
Eman A Al-ShahariHealth Specialties, Basic Sciences and Their Applications Unit, Applied College at Muhayil Asir, King Khalid University, Abha 61421, Saudi Arabia.
Zakaria A SalihResearch and Training Station, King Faisal University, P.O. Box 400, Al-Ahsa 31982, Saudi Arabia.
Mohammed Ali Al-DuaisDepartment of Biochemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia.
Ahmed El-SayedDepartment of Animal Health and Poultry, Animal and Poultry Production Division, Desert Research Center (DRC), Cairo 11753, Egypt.

Funding

Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2025R454) PNURSP2025R454
6 · The paper itself

Abstract

Sheep pox, caused by sheep pox virus (SPV), is a transboundary disease that threatens sheep production and trade. This study aimed to identify genetic, immunological, and biochemical markers associated with susceptibility to SPV in Barki ewes. A total of 100 adult ewes were examined, including 50 clinically healthy and 50 naturally infected animals. PCR detected SPV DNA in 60% of suspected scab samples, highlighting diagnostic challenges in field investigations. Blood samples were analyzed for hematological indices, cytokine profiles, acute phase proteins, oxidative stress biomarkers, iron metabolism, and hormonal parameters. Expression profiles and single-nucleotide polymorphisms (SNPs) in 15 immune and antioxidant genes were characterized from cDNA-derived sequences. Infected animals exhibited microcytic hypochromic anemia, leukocytosis, elevated proinflammatory cytokines, and reduced IL-10. Acute phase proteins, oxidative stress markers, and cortisol were increased, whereas antioxidant capacity and transferrin were reduced. Twenty-three SNPs were identified, including non-synonymous variants, which showed promising but unvalidated associations with disease status. These findings highlight immune, oxidative, and genetic alterations in SPV-infected sheep, but further longitudinal and cross-validated studies are needed to establish their diagnostic or breeding utility.

Indexed as

antioxidantsgene expressionimmunitysheep poxSNPs

Identifiers

PMID41012793
PMCPMC12474403

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.