SynthesisBMC anesthesiology2025
The effect of sugammadex on postoperative urinary retention and recovery characteristics: a systematic review and meta-analysis.
Synthesis in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sugammadex and intraocular pressure: systematic review with meta-analysis and trial sequential analysis.BMC anesthesiology · 2026Pooled it
- Impact of Sugammadex on Clinical and Patient-Centered Outcomes: Beyond Neuromuscular Recovery.Journal of clinical medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostoperative urinary retention (POUR) is a frequent complication following general anesthesia. There is growing interest in whether sugammadex, a neuromuscular blockade (NMB) reversal agent that does not require anticholinergic coadministration, might reduce its incidence. This systematic review and meta-analysis aimed to evaluate the effects of sugammadex on POUR and other postoperative recovery outcomes, such as 30-day readmission rates and postoperative pain scores (POPS).
methodsPubMed, Cochrane, Embase, and Web of Science were comprehensively searched for studies published through June 3, 2024. Randomized controlled trials (RCTs) and cohort studies comparing sugammadex with conventional reversal agents or no reversal agents were included. Meta-analysis was performed using Stata 15.1 to synthesize the results.
resultsThe analysis ultimately included 25 studies involving a total of 163,367 patients: 84,362 received sugammadex, while 79,005 received neostigmine, or did not receive an antagonist.Meta-analysis revealed a significant reduction in the incidence of POUR with sugammadex use (Relative Risk (RR): 0.47, 95% Confidence Interval (CI): 0.34-0.64, P < 0.001). No meaningful differences were observed in POPS (Standardized Mean Difference (SMD): -0.01, 95% CI: -0.43-0.40, P = 0.945) or 30-day readmission rates (RR: 0.81, 95% CI: 0.65-1.01, P = 0.057).
conclusionThese findings suggest that sugammadex substantially reduces POUR incidence, with no significant impact on POPS or 30-day readmission rates. Further research is warranted to explore its role in diverse patient populations and surgical procedures and to investigate its potential influence on postoperative pain management and readmission rates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.