ArticleBMC cardiovascular disorders2025
Association of weight-adjusted waist index with all-cause and cardiovascular mortality in patients with metabolic dysfunction-associated steatotic liver disease: a national population-based cohort study.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Obesity as a predictor of atherogenic dyslipidemia in patients with metabolic dysfunction associated steatotic liver disease.Scientific reports · 2026Article
- Association of cholesterol, high-density lipoprotein and glucose (CHG) index with mortality risk in metabolic dysfunction-associated steatotic liver disease (MASLD) adults: results from two prospective cohorts.Cardiovascular diabetology · 2026Article
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Authors and funding
4 authors.
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Abstract
objectiveThis study aims to investigate the correlation between weight-adjusted waist index (WWI) and all-cause and cardiovascular mortality in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and to determine whether WWI can be utilized as an independent predictor for prognostic assessment in patients with MASLD.
methodsThis study was based on data from the 1999-2018 National Health and Nutrition Examination Survey database, which included 17,785 patients with MASLD. The diagnosis of MASLD was based on calculating fatty liver index values and combining five cardiometabolic criteria. Cox proportional hazard regression models were employed to examine the relationship between WWI and all-cause mortality and cardiovascular mortality in patients with MASLD while adjusted for potential confounding variables such as gender, age, and race. Furthermore, the dose-response relationship between WWI and mortality was evaluated using Kaplan-Meier survival curves and restricted cubic spline plots (RCS). Subgroup analyses were conducted to investigate the prognostic impact of different clinical characteristics.
resultsThe results demonstrated that WWI significantly and positively correlated with all-cause and cardiovascular mortality in patients with MASLD. The association between WWI and mortality remained statistically significant after adjustment for multiple potential confounding variables. The Kaplan-Meier survival curve analysis demonstrated a significant increase in all-cause and cardiovascular mortality with increasing quartiles of WWI. The RCS analysis showed a linear dose-response relationship between WWI and mortality in patients with MASLD. Subgroup analyses revealed discrepancies in the predictive impact of WWI on mortality across different clinical characteristics, yet the overall trend remained consistent.
conclusionsThe present study demonstrated that WWI is a valid indicator for assessing the degree of obesity and a significant predictor of prognosis in patients with MASLD. Higher WWI was found to be significantly associated with higher all-cause mortality and cardiovascular mortality in MASLD patients.
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