ArticleBMC gastroenterology2025
Association between the TyG index and MAFLD and its subtypes: a population-based cross-sectional study.
Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The role of pre-operative sit-to-stand assessment in robotic hysterectomy surgical outcomes: An observational cohort study.Gynecologic oncology reports · 2026Article
- Diabetes Duration Is Associated with Declining Kidney Function: eGFR and CKD Burden Across Duration.Journal of clinical medicine · 2026Article
- Simplicity meets accuracy: TyG-Waist as a practical alternative to CVAI for type 2 diabetes prediction in high-risk Chinese adults.BMC endocrine disorders · 2026Article
- Triglyceride glucose index versus triglyceride glucose-BMI index in non-alcoholic fatty liver disease: A correlation with steatosis and fibrosis.Bioinformation · 2026Article
- Integrative Assessment of TyG Index, FIB-4, and eGFR as Composite Predictors of Metabolic Risk Clusters in Adults.Metabolites · 2025Article
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Authors and funding
7 authors.
Funding
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Abstract
backgroundThe association between triglyceride-glucose (TyG) index and metabolic dysfunction-associated fatty liver disease (MAFLD) and its subtypes in the U.S. population remains unclear. This study aims to investigate this relationship.
methodsThis study involved individuals aged 20 years or older who were not pregnant from the National Health and Nutrition Examination Survey (NHANES) between the years 2017 and 2020. MAFLD diagnosis was established by identifying the occurrence of liver steatosis through ultrasound transient elastography, along with the presence of one or more of the following disorders: diabetes mellitus (DM), overweight or obesity, or metabolic disorders. We evaluated the association between TyG index and MAFLD using multivariable regression analysis.
resultsOur study included 2966 participants with a mean age of 46.9 ± 16.5 years. As TyG quartiles increased, MAFLD incidence increased (P < 0.001). Full model adjustment indicated that TyG was independently connected with MAFLD (OR = 2.53; 95% CI = 2.13-3.00]), with the maximum quartile exhibiting the highest risk. In men, the TyG index and MAFLD exhibit a nonlinear J-shaped relationship (P = 0.042), whereas in women, the relationship was linear and positive (P = 0.204). This association was found to be more pronounced in Mexican Americans, those who were not overweight or obese, and among individuals without chronic kidney disease (CKD) (all P for interaction < 0.05).
conclusionsThe TyG index was an independent risk factor for MAFLD. Individuals with various MAFLD components require individualized management.
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