ArticleJournal of orthopaedic surgery and research2025
The clinical application potential of miR-1287-5p in spinal cord injury resulting from spinal trauma and its involvement in modulating the inflammatory response.
Article in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Profiling miRNA in Systemic Lupus Erythematosus Patients Adhering to a Mediterranean Diet: An Interventional Pilot Study.Journal of clinical medicine · 2026Article
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Authors and funding
4 authors.
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Abstract
backgroundSpinal cord injury (SCI) is a severe nervous trauma and the underlying mechanism of miR-1287-5p in its pathogenesis remains incompletely elucidated.
objectiveThis research seeks to elucidate the molecular mechanism of miR-1287-5p in regulating inflammatory responses following SCI.
methodsThe expression levels of miR-1287-5p and MAP3K9 were measured using qRT-PCR. Pearson correlation tests scrutinised their associations with clinical indices. ROC curve analysis was conducted to evaluate it diagnostic value for SCI. CCK-8 and ELISA assays were employed to evaluate cell viability and protein expression levels, respectively. The direct interaction between miR-1287-5p and MAP3K9 was confirmed through dual-luciferase reporter assays.
resultsmiR-1287-5p was markedly down-regulated in SCI patients and correlated with pain scores, LEMS, and ASIA grade.ROC curve analysis indicated that miR-1287-5p has potential as a diagnostic biomarker for SCI. Overexpression of miR-1287-5p enhances cell viability, reduces the production of inflammatory cytokines, and specifically binds to MAP3K9, thereby inhibiting its expression.
conclusionmiR-1287-5p serves as a potential diagnostic biomarker for SCI and modulates the inflammatory response in SCI through direct targeting of MAP3K9.
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