Evidence map›Paper›PMID 41013728›Full record

ArticleStem cell research & therapy2025

TAZ enhances the activity of the AKT signaling pathway to promote adipogenesis of gADSCs.

Mei Zhou, Hongyan Zhang, Xiong Miao, Ying Zhao, Long Zhu, Jie Liu, Dongjun Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mei Zhou *State Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, Inner Mongolia University, Hohhot, 010021, Inner Mongolia, China.
Hongyan Zhang *State Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, Inner Mongolia University, Hohhot, 010021, Inner Mongolia, China.
Xiong Miao *Agricultural and Animal Husbandry Technology Extension Centre, Etuoke Banner, Inner Mongolia, China.
Ying ZhaoInner Mongolia Agricultural and Livestock Product Quality and Safety Center, Hohhot, Inner Mongolia, China.
Long ZhuState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, Inner Mongolia University, Hohhot, 010021, Inner Mongolia, China.
Jie LiuState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, Inner Mongolia University, Hohhot, 010021, Inner Mongolia, China.
Dongjun LiuState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, Inner Mongolia University, Hohhot, 010021, Inner Mongolia, China. 18586050523@163.com.ORCID http://orcid.org/0000-0002-3201-0559

Funding

Joint Fund for Regional Innovation and Development of the National Natural Science Foundation of China U23A20226Science and Technology Planning Project of Inner Mongolia Autonomous Region 2023KYPT0014
6 · The paper itself

Abstract

Adipose-derived mesenchymal stem cells (ADSCs) possess the capacity for multidirectional differentiation, including differentiation into adipocytes. However, the molecular mechanisms that control adipogenesis are not yet fully understood.Transcriptional co-activator with PDZ-binding motif (TAZ) can act as a molecular rheostat, finely regulating the balance between osteoblast and adipocyte differentiation. In this study, we investigated whether TAZ plays a role in the adipogenesis of goat ADSCs (gADCS). Our results indicated that the expression of TAZ increased during adipogenesis of gADSCs. We established gADSCs cell lines with stable TAZ overexpression and knockdown. We found that TAZ overexpression promoted the adipogenesis of gADSCs, whereas its knockdown inhibited this process. Furthermore, TAZ overexpression and knockdown altered the nuclear expression of Yes-associated protein(YAP) and TAZ. Subsequent analyses indicated that TAZ overexpression increased AKT phosphorylation levels. Moreover, treatment with a PI3K inhibitor (LY294002) abrogated the TAZ-induced increase in adipogenesis, suggesting that TAZ regulates the adipogenesis of gADSCs via the PI3K/AKT pathway. Collectively, our results indicate that TAZ promotes the adipogenesis of gADSCs by enhancing the activity of the PI3K/AKT signaling pathway.

Indexed as

AdipogenesisMesenchymal Stem CellsProto-Oncogene Proteins c-aktAdipocytesAnimalsCell DifferentiationChromonesGoatsMorpholinesPhosphatidylinositol 3-KinasesSignal TransductionTrans-ActivatorsTranscriptional Coactivator with PDZ-Binding Motif ProteinsTranscription Factors2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneChromonesMorpholinesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTrans-ActivatorsTranscriptional Coactivator with PDZ-Binding Motif ProteinsTranscription FactorsAdipogenesisAdipose mesenchymal stem cellsPI3K/AKTTAZ

Identifiers

PMID41013728
PMCPMC12465564

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.