ArticleCardiovascular diabetology. Endocrinology reports2025
DPP4 inhibitors and COVID19 outcomes in patients with type II diabetes: a multicenter retrospective cohort study in Saudi Arabia.
Article in Cardiovascular diabetology. Endocrinology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Association of Dipeptidyl Peptidase-4 Inhibitor Use with COVID-19 Mortality in Diabetic Patients: A Nationwide Cohort Study in Korea.Journal of clinical medicine · 2025Article
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18 authors.
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Abstract
Dipeptidyl peptidase-4 inhibitors (DPP-4is) have been hypothesized to impact COVID-19 outcomes by modulating immune and inflammatory responses. This study aimed to assess the association between DPP-4i use and COVID-19 severity in patients with type 2 diabetes. Adult (≥ 18 years) patients with T2DM hospitalized for COVID-19 across seven hospitals in Saudi Arabia between March 2020 and November 2021 were included. Outcomes were in-hospital mortality, progression to mechanical ventilation (MV), intensive care unit (ICU) admission, and length of stay. We performed time-to-event analyses using Cox proportional hazards models with propensity score weighting to account for confounders. Ordinal proportional odds model were for the length of stay outcomes. A total of 166 patients were included in the DPP-4i group, and 351 were included in the non-DPP-4i group. Propensity score weighting achieved a well-balanced comparison between the groups. The DPP-4i group showed a nonsignificant decrease in mortality (adjusted hazard ratio [HRadj] = 0.73; 95% confidence interval [CI]: 0.40-1.34; p = 0.319), a significant reduction in progression to MV (HRadj = 0.40; 95% CI: 0.21-0.77; p = 0.006), and a nonsignificant reduction in ICU admissions (HRadj = 0.83; 95% CI: 0.57-1.21; p = 0.338). Length of stay did not differ significantly between groups. This study revealed that prior usage of DPP-4is in T2DM patients with COVID-19 is linked to a significant reduction in progression to MV in this high-risk group. However, there is a need for further investigation through well-powered prospective studies and randomized controlled trials to confirm these findings.
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