Evidence map›Paper›PMID 41014333›Full record

Trial reportMedical microbiology and immunology2025

Effect of controlled human Plasmodium falciparum infection on B cell subsets in individuals with different levels of malaria immunity.

Pilar Requena, Gloria Patricia Gómez-Pérez, Matthew B B McCall, Diana Barrios, Ruth Aguilar, Julia Fernández-Morata, Marta Vidal, Joseph J Campo, Carla Sanchez, Maria Yazdabankhsh and 7 more

Abstract readClinical Trial, Phase IRandomized Controlled Trial
In one paragraph

Trial report in Medical microbiology and immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Pilar RequenaFacultad de Farmacia, Departamento de Medicina Preventiva y Salud Pública, Universidad de Granada, Campus de Cartuja S/N 18170, Granada, Spain. prequena@ugr.es.ORCID http://orcid.org/0000-0002-2298-4085
Gloria Patricia Gómez-PérezISGlobal, Barcelona, Catalonia, Spain.
Matthew B B McCallISGlobal, Barcelona, Catalonia, Spain.
Diana BarriosISGlobal, Barcelona, Catalonia, Spain.
Ruth AguilarISGlobal, Barcelona, Catalonia, Spain.
Julia Fernández-MorataISGlobal, Barcelona, Catalonia, Spain.
Marta VidalISGlobal, Barcelona, Catalonia, Spain.
Joseph J CampoAntigen Discovery, Irvine, CA, USA.
Carla SanchezISGlobal, Barcelona, Catalonia, Spain.
Maria YazdabankhshLeiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, ZA, Netherlands.
B Kim Lee SimFacultad de Farmacia, Departamento de Medicina Preventiva y Salud Pública, Universidad de Granada, Campus de Cartuja S/N 18170, Granada, Spain.
Stephen L HoffmanSanaria Inc., Rockville, MD, USA.
Peter KremsnerCentre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.
Bertrand LellCentre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.
Benjamin MordmüllerDepartment of Medical Microbiology, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
Carlota Dobaño *ISGlobal, Barcelona, Catalonia, Spain.
Gemma Moncunill *ISGlobal, Barcelona, Catalonia, Spain. gemma.moncunill@isglobal.org.ORCID http://orcid.org/0000-0001-5105-9836

Funding

Baseline host and environmental factors that impact pre-erythrocytic malaria vaccine (hypo)responsiveness in endemic regionsU01AI165745 · NIAID · LEIDEN UNIVERSITY MEDICAL CENTER · PI Maria Yazdanbakhsh · 2022 to 2026
$3.3M
Understanding RTS,S malaria vaccine-induced protection through integrated analysiR01AI095789 · NIAID · BARCELONA INTERNATIONAL HEALTH RES CTR · PI DOBANO, CARLOTA · 2012 to 2016
$3.2M
NIAID NIH HHS R01 AI095789NIAID NIH HHS U01 AI165745
6 · The paper itself

Abstract

Continuous exposure to Plasmodium falciparum (Pf) has been associated with alterations in B cells. We investigated the effect of controlled human malaria infection (CHMI) on B cell phenotypes in individuals with different Pf immunity status: malaria-naïve, immunized with PfSPZ-CVac and semi-immune (lifelong-exposed) volunteers. Compared to naïve, semi-immune but not vaccinated individuals, had increased baseline frequencies of immature B cells (CD19

Indexed as

B-Lymphocyte SubsetsMalaria, FalciparumPlasmodium falciparumAdolescentAdultAntibodies, ProtozoanFemaleHumansImmunoglobulin GMalaria VaccinesMaleMiddle AgedYoung AdultAntibodies, ProtozoanImmunoglobulin GMalaria VaccinesB cellsControlled human malaria infectionCytokinesPlasmodium falciparum

Identifiers

PMID41014333
PMCPMC12476306

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.