Evidence map›Paper›PMID 41014339›Full record

ArticlePsychopharmacology2026

Targeting synaptic plasticity and acetylcholine dysregulation in the medial prefrontal cortex: Rosmarinic acid attenuates Autism-like phenotypes in Shank3B

Jiahui Shi, Mei Chen, Yushu Zhang, Xiaotang Fan, Lian Wang, Huiling Liao

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Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jiahui Shi *Geriatric Department, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Mei Chen *Department of Military Cognitive Psychology, School of Psychology, Third Military Medical University (Army Medical University), Chongqing, China.
Yushu ZhangGeriatric Department, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Xiaotang FanDepartment of Military Cognitive Psychology, School of Psychology, Third Military Medical University (Army Medical University), Chongqing, China. fanxiaotang@tmmu.edu.cn.
Lian WangDepartment of Military Cognitive Psychology, School of Psychology, Third Military Medical University (Army Medical University), Chongqing, China. wl1209@tmmu.edu.cn.
Huiling LiaoNeurology Department, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China. liaohl@swmu.edu.cn.

Funding

Affiliated Hospital of Southwest Medical University 2022-CXTD-05Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission NO. cstc2021jcyj-msxmX0469
6 · The paper itself

Abstract

rationaleAutism spectrum disorder (ASD) is characterized by cognitive deficits, repetitive behaviors, and social impairments. The SH3 and multiple ankyrin repeat domains protein 3B-deficient (Shank3B

objectiveThis study aimed to investigate the therapeutic effects and potential molecular mechanisms of RosA in alleviating behavioral dysfunction in Shank3B

methodsSocial deficits were evaluated using the three-chamber social test and the male-male social interaction test. Repetitive behaviors were assessed through the self-grooming and marble-burying tests. Cognitive and memory functions were measured using novel object recognition, the Y-maze, and nesting behavior tests. The open field test was employed to evaluate motor functions and exploratory activities. High-throughput RNA sequencing (RNA-seq) was used to identify key genes in the medial prefrontal cortex (mPFC) of the different groups of mice. Neurotransmitter levels of acetylcholine (ACh) and γ-aminobutyric acid (GABA) were analyzed via ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and high-performance liquid chromatography (HPLC), respectively. Additionally, synaptic function and plasticity in the mPFC were assessed by measuring Postsynaptic Density Protein 95 (PSD95) expression and the activation of the p-CREB/BDNF signaling pathway.

resultsRosA significantly improved repetitive behaviors, as well as cognitive and memory abilities, in Shank3B

conclusionRosA alleviates cognitive deficits and repetitive behaviors in Shank3B

Indexed as

AcetylcholineAutism Spectrum DisorderCinnamatesDepsidesNeuronal PlasticityPrefrontal CortexAnimalsBehavior, AnimalBrain-Derived Neurotrophic FactorCyclic AMP Response Element-Binding ProteinDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutMicrofilament ProteinsAcetylcholineBdnf protein, mouseBrain-Derived Neurotrophic FactorCinnamatesCreb1 protein, mouseCyclic AMP Response Element-Binding ProteinDepsidesMicrofilament ProteinsNerve Tissue ProteinsRosmarinic AcidShank3 protein, mouseAcetylcholineAutism spectrum disorderCREB/BDNFGABARosmarinic acid

Identifiers

PMID41014339

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.