ArticleSchizophrenia research2025
Age- and sex-dependent effects of stressors on activity of the nucleus reuniens of the thalamus.
Article in Schizophrenia research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Parvalbumin and anxiety across development in female offspring of the MAM neurodevelopmental model of schizophrenia.Journal of psychiatric research · 2026Article
- The thalamic nucleus reuniens orchestrates prefrontal-hippocampal synchrony in memory, emotion, and disease.Frontiers in behavioral neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
backgroundStress is a significant socio-environmental risk factor for schizophrenia, with its impact varying with age and sex. Male rats are more vulnerable to the long-term effecct of stress during early adolescence, whereas females are more affected during late adolescence, with both demonstrating a stress-induced hyperdopaminergic state and ventral hippocampal hyperexcitability. The nucleus reuniens of the thalamus (RE) plays a crucial role in modulating hippocampal-prefrontal connectivity and dopamine activity. This study investigated the effect of stress during neurodevelopment on RE activity in both sexes. STUDY
designSprague-Dawley rats were subjected to a 10-day footshock and restraint stress protocol during early adolescence (Post-natal day [PD] 31-40) or late adolescence (PD41-50) periods. Electrophysiological RE recordings were conducted 1-2 and 5-6 weeks post-stress. STUDY
resultsEarly adolescence stress did not affect the number of spontaneously active RE neurons in males and females after 1-2 or 5-6 weeks, but it increased the proportion of RE neurons firing in bursts in females. Late adolescence stress increased the number of spontaneously active RE neurons in females at both 1-2 and 5-6 weeks. Females had fewer active RE neurons than males starting earlier in adulthood but not at a younger age (PD47-54). This shows an age-dependent effect on female RE activity.
conclusionStress had sex-specific effects on RE neuron activity of females, with late adolescence stress increasing the number of spontaneous RE neurons, while early adolescence stress influenced burst firing. Therefore, stress-induced changes in RE activity during adolescence may contribute to females' vulnerability to neuropathology.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.