ArticleCell host & microbe2025
A Bacteroides fragilis protease activates host PAR
Abstract read
In one paragraph
Article in Cell host & microbe, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The relationship between diabetic retinopathy and intestinal microbiota: a systematic review and meta analysis.International ophthalmology · 2026Pooled it
- The protease code of the bacterial gut microbiota: ecological regulation, barrier disruption, and rewiring host defense and signaling.Gut microbes · 2026Review
- The Serine Protease-Serine Protease Inhibitor Regulatory Network in Inflammatory Bowel Disease: From Molecular Mechanisms to Novel Therapeutic Horizons.Journal of advanced research · 2026Review
- Marine-Derived Proteins: Individual Variability in Health Effects Across Protein Structure, Host Genetics, and Gut Microbiota.Comprehensive reviews in food science and food safety · 2026Review
- Protease-Activated Receptor-2 as a Proteolytic Rheostat in Colorectal and Pancreatic Cancer: From Mechanism to Biomarker-Guided Therapy.International journal of molecular sciences · 2026Review
- A Global Ligandability Map of Tryptoline Butynamide Stereoprobes Identifies Covalent Inhibitors of the Actin Maturation Protease.Journal of the American Chemical Society · 2026Article
- A Review on the Molecular Dynamics of EnterotypeInternational journal of molecular sciences · 2026Review
- Article
- A Global Ligandability Map of Tryptoline Butynamide Stereoprobes Identifies Covalent Inhibitors of the Actin Maturation Protease ACTMAP.bioRxiv : the preprint server for biology · 2026Article
- Proteases and Abdominal Pain-Old Dog, New (Microbial) Tricks.Cellular and molecular gastroenterology and hepatology · 2026Review
- Some aspects of trypsin's involvement in the regulation of physiological functions.Frontiers in molecular biosciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Markus LakemeyerInstitute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, 07743 Jena, Germany; Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, 07743 Jena, Germany; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: markus.lakemeyer@uni-jena.de.
Rocco LatorreDepartment of Molecular Pathobiology, NYU Dentistry, New York, NY 10010, USA; Pain Research Center, NYU Dentistry, New York, NY 10010, USA.
Kristyna BlazkovaDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Hannah M WoodGastrointestinal Diseases Research Unit, Queen's University, Kingston, ON K7L 3N6, Canada.
Dane D JensenDepartment of Molecular Pathobiology, NYU Dentistry, New York, NY 10010, USA; Pain Research Center, NYU Dentistry, New York, NY 10010, USA; Translational Research Center, NYU Dentistry, New York, NY 10010, USA; Department of Oral and Maxillofacial Surgery, NYU Dentistry, Bluestone Center for Clinical Research, New York, NY 10010, USA.
Nayab ShakilInstitute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, 07743 Jena, Germany.
Scott C ThomasDepartment of Molecular Pathobiology, NYU Dentistry, New York, NY 10010, USA.
Deepak SaxenaDepartment of Molecular Pathobiology, NYU Dentistry, New York, NY 10010, USA.
Yatendra MulpuriDepartment of Molecular Pathobiology, NYU Dentistry, New York, NY 10010, USA.
David PoolmanDepartment of Molecular Pathobiology, NYU Dentistry, New York, NY 10010, USA; Pain Research Center, NYU Dentistry, New York, NY 10010, USA.
Paz DuranDepartment of Molecular Pathobiology, NYU Dentistry, New York, NY 10010, USA; Pain Research Center, NYU Dentistry, New York, NY 10010, USA; Translational Research Center, NYU Dentistry, New York, NY 10010, USA; Department of Oral and Maxillofacial Surgery, NYU Dentistry, Bluestone Center for Clinical Research, New York, NY 10010, USA.
Laura J KellerDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
David E ReedGastrointestinal Diseases Research Unit, Queen's University, Kingston, ON K7L 3N6, Canada.
Brian L SchmidtDepartment of Molecular Pathobiology, NYU Dentistry, New York, NY 10010, USA; Pain Research Center, NYU Dentistry, New York, NY 10010, USA; Translational Research Center, NYU Dentistry, New York, NY 10010, USA; Department of Oral and Maxillofacial Surgery, NYU Dentistry, Bluestone Center for Clinical Research, New York, NY 10010, USA.
Néstor N Jiménez-VargasGastrointestinal Diseases Research Unit, Queen's University, Kingston, ON K7L 3N6, Canada.
Fangxi XuDepartment of Molecular Pathobiology, NYU Dentistry, New York, NY 10010, USA.
Alan E LomaxGastrointestinal Diseases Research Unit, Queen's University, Kingston, ON K7L 3N6, Canada.
Nigel W BunnettDepartment of Molecular Pathobiology, NYU Dentistry, New York, NY 10010, USA; Pain Research Center, NYU Dentistry, New York, NY 10010, USA. Electronic address: nwb2@nyu.edu.
Matthew BogyoDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: mbogyo@stanford.edu.
Funding
Targeting bacterial proteases involved in PAR signaling to treat inflammatory bowel diseasesR01DK130293 · NIDDK · STANFORD UNIVERSITY · PI BOGYO, MATTHEW · 2021 to 2025
$2.4MMechanisms of Endosomal Signaling of ItchR01NS125413 · NINDS · NEW YORK UNIVERSITY · PI Dane D Jensen · 2022 to 2026
$1.9MA Modern Flexible Mass Spectrometry Platform for Advancing Proteomics ResearchS10OD030473 · OD · STANFORD UNIVERSITY · PI LEIB, RYAN D. · 2021 to 2021
$1.3MStanford Chem-H Chemistry/Biology Interface Predoctoral Training ProgramT32GM120007 · NIGMS · STANFORD UNIVERSITY · PI BERTOZZI, CAROLYN · 2016 to 2020
$1.2MMolecular Pharmacology Training GrantT32GM113854 · NIGMS · STANFORD UNIVERSITY · PI MOCHLY-ROSEN, DARIA · 2015 to 2019
$1.1MNIDDK NIH HHS R01 DK130293NIGMS NIH HHS T32 GM113854NIGMS NIH HHS T32 GM120007NIH HHS S10 OD030473NINDS NIH HHS R01 NS125413
Abstract
Protease-activated receptor 2 (PAR
Indexed as
Bacterial ProteinsBacteroides fragilisInflammationReceptor, PAR-2Serine ProteasesAnimalsDisease Models, AnimalGastrointestinal MicrobiomeHumansInflammatory Bowel DiseasesIrritable Bowel SyndromeMaleMiceMice, Inbred C57BLBacterial ProteinsF2rl1 protein, mouseReceptor, PAR-2Serine Proteasesactivity-based probegut microbiotainflammationinflammatory bowel diseaseintestinal organoidsirritable bowel syndromepain signalingproteaseprotease-activated receptors
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.