Evidence map›Paper›PMID 41015263›Full record

ArticleThe Journal of infection2025

Independent and interactive effects of viral species on early-life lower respiratory tract illness.

Camille M Moore, Elizabeth A Secor, Ana Fairbanks-Mahnke, Jamie L Everman, Jennifer R Elhawary, Jonathan I Witonsky, Elmar Pruesse, Chih-Hao Chang, Maria G Contreras, Celeste Eng and 27 more

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Article in The Journal of infection, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

37 authors.

Camille M MooreCenter for Genes, Environment & Health, National Jewish Health, 1400 Jackson St, Smith Building, Denver, CO 80206, USA; Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, 13001 E. 17th Place, Mail Stop B119, Aurora, CO 80045, USA. Electronic address: mooreca@njhealth.org.
Elizabeth A SecorCenter for Genes, Environment & Health, National Jewish Health, 1400 Jackson St, Smith Building, Denver, CO 80206, USA. Electronic address: secore@njhealth.org.
Ana Fairbanks-MahnkeCenter for Genes, Environment & Health, National Jewish Health, 1400 Jackson St, Smith Building, Denver, CO 80206, USA. Electronic address: ana.fairbanks-mahnke@cuanschutz.edu.
Jamie L EvermanCenter for Genes, Environment & Health, National Jewish Health, 1400 Jackson St, Smith Building, Denver, CO 80206, USA. Electronic address: evermanj@njhealth.org.
Jennifer R ElhawaryDepartment of Medicine, University of California, San Francisco, 1550 Fourth Street, San Francisco, CA 94158, USA. Electronic address: jennifer.elhawary@ucsf.edu.
Jonathan I WitonskyDepartment of Pediatrics, University of California, San Francisco, 550 16th Street, San Francisco, CA 94158, USA. Electronic address: jonathan.witonsky@ucsf.edu.
Elmar PruesseCenter for Genes, Environment & Health, National Jewish Health, 1400 Jackson St, Smith Building, Denver, CO 80206, USA. Electronic address: pruessee@njhealth.org.
Chih-Hao ChangDepartment of Medicine, University of California, San Francisco, 1550 Fourth Street, San Francisco, CA 94158, USA. Electronic address: chihhao.chang@ucsf.edu.
Maria G ContrerasDepartment of Medicine, University of California, San Francisco, 1550 Fourth Street, San Francisco, CA 94158, USA. Electronic address: maria.contreras@ucsf.edu.
Celeste EngDepartment of Medicine, University of California, San Francisco, 1550 Fourth Street, San Francisco, CA 94158, USA. Electronic address: celeste.eng@ucsf.edu.
Keyshla CanalesCentro de Neumología Pediátrica, 735 Av. de la Constitución, San Juan 00917, PR, USA. Electronic address: keyshlacanales@hotmail.com.
Tsunami RosadoCentro de Neumología Pediátrica, 735 Av. de la Constitución, San Juan 00917, PR, USA. Electronic address: tsunamirosado.primero@gmail.com.
Donglei HuDepartment of Medicine, University of California, San Francisco, 1550 Fourth Street, San Francisco, CA 94158, USA. Electronic address: donglei.hu@ucsf.edu.
Scott HuntsmanDepartment of Medicine, University of California, San Francisco, 1550 Fourth Street, San Francisco, CA 94158, USA. Electronic address: scott.huntsman@ucsf.edu.
Nathan D JacksonCenter for Genes, Environment & Health, National Jewish Health, 1400 Jackson St, Smith Building, Denver, CO 80206, USA. Electronic address: jacksonn@njhealth.org.
Yingchun LiCenter for Genes, Environment & Health, National Jewish Health, 1400 Jackson St, Smith Building, Denver, CO 80206, USA. Electronic address: liyingchun@njhealth.org.
Natalie LopezCentro de Neumología Pediátrica, 735 Av. de la Constitución, San Juan 00917, PR, USA. Electronic address: natalie.lopez1@outlook.com.
Annette Medina ValentinCentro de Neumología Pediátrica, 735 Av. de la Constitución, San Juan 00917, PR, USA.
Vivian MedinaCentro de Neumología Pediátrica, 735 Av. de la Constitución, San Juan 00917, PR, USA. Electronic address: annette.medinavalentin@gmail.com.
Chris Angely Montanez-LopezCentro de Neumología Pediátrica, 735 Av. de la Constitución, San Juan 00917, PR, USA. Electronic address: cmontanez23@stu.psm.edu.
Andrew MorinCenter for Genes, Environment & Health, National Jewish Health, 1400 Jackson St, Smith Building, Denver, CO 80206, USA. Electronic address: andrew.morin232@gmail.com.
Natalie A NievesCentro de Neumología Pediátrica, 735 Av. de la Constitución, San Juan 00917, PR, USA. Electronic address: nnieves3208@gmail.com.
Sam S OhDepartment of Medicine, University of California, San Francisco, 1550 Fourth Street, San Francisco, CA 94158, USA. Electronic address: sam.s.oh@gmail.com.
Richeliz Alfonso OteroCentro de Neumología Pediátrica, 735 Av. de la Constitución, San Juan 00917, PR, USA. Electronic address: richeliz.alfonso.otero@gmail.com.
Raymarie ColonCentro de Neumología Pediátrica, 735 Av. de la Constitución, San Juan 00917, PR, USA. Electronic address: raymariecolon.primero@gmail.com.
Leysha RodriguezCentro de Neumología Pediátrica, 735 Av. de la Constitución, San Juan 00917, PR, USA. Electronic address: lele2994@yahoo.com.
Satria P SajuthiCenter for Genes, Environment & Health, National Jewish Health, 1400 Jackson St, Smith Building, Denver, CO 80206, USA. Electronic address: satriaps@gmail.com.
Sandra SalazarDepartment of Medicine, University of California, San Francisco, 1550 Fourth Street, San Francisco, CA 94158, USA. Electronic address: sandra.salazar@ucsf.edu.
Gonzalo SerranoCentro de Neumología Pediátrica, 735 Av. de la Constitución, San Juan 00917, PR, USA. Electronic address: gonzalourielserrano@gmail.com.
Emily Vazquez MoralesCentro de Neumología Pediátrica, 735 Av. de la Constitución, San Juan 00917, PR, USA. Electronic address: em.vazquezm15@gmail.com.
Gabriela VazquezCentro de Neumología Pediátrica, 735 Av. de la Constitución, San Juan 00917, PR, USA. Electronic address: gabriela.vazquez11@upr.edu.
Nicole Vazquez MoralesCentro de Neumología Pediátrica, 735 Av. de la Constitución, San Juan 00917, PR, USA. Electronic address: nicolevazquez.primero@gmail.com.
Blake J M WilliamsCenter for Genes, Environment & Health, National Jewish Health, 1400 Jackson St, Smith Building, Denver, CO 80206, USA. Electronic address: blake.jm.williams@gmail.com.
Priscilla ZhangDepartment of Medicine, University of California, San Francisco, 1550 Fourth Street, San Francisco, CA 94158, USA. Electronic address: priscilla.zhang@ucsf.edu.
Dean SheppardDepartment of Medicine, University of California, San Francisco, 1550 Fourth Street, San Francisco, CA 94158, USA. Electronic address: dean.sheppard@ucsf.edu.
José R Rodríguez SantanaCentro de Neumología Pediátrica, 735 Av. de la Constitución, San Juan 00917, PR, USA. Electronic address: jr@pedasthma.com.
Max A SeiboldCenter for Genes, Environment & Health, National Jewish Health, 1400 Jackson St, Smith Building, Denver, CO 80206, USA; Department of Pediatrics, National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA; Department of Pediatrics and Division of Pulmonary Sciences and Critical Care Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, 12700 East 19th Avenue, 9C03, Aurora, CO 80045, USA. Electronic address: seiboldm@njhealth.org.

Funding

Natural History of Viral Induced Airway Dysfunction and Asthma in Minority ChildrenU01HL138626 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RODRIGUEZ-SANTANA, JOSE, SEIBOLD, MAX A · 2018 to 2022
$10.0M
Improving Prediction of Asthma-related Outcomes with Genetic Ancestry-informed Lung Function EquationsK23HL169911 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jonathan Witonsky · 2023 to 2026
$688k
NHLBI NIH HHS K23 HL169911NHLBI NIH HHS U01 HL138626
6 · The paper itself

Abstract

objectivesTo determine the association between viral species and odds of severe lower respiratory tract illnesses (sLRI) versus upper respiratory illness (URI) among children under 2 years of age.

methodsInfants (n=2061) enrolled in the Puerto Rican Infant Metagenomic and Epidemiologic Study of Respiratory Outcomes were surveilled for respiratory illnesses until age 2 years (March 2020 to April 2024). Nasal swabs from 1363 illnesses (774 participants) were screened for 21 pathogens.

resultsRSV infections occurred in 23% of sLRIs and increased odds of sLRI vs URI (OR=9.28; 95% CI, 5.43-15.85). Metapneumovirus, parainfluenza, and non-SARS-CoV-2 coronavirus also increased odds of sLRIs, while SARS-CoV-2 was associated with lower risk of sLRIs. Rhinovirus (43%) and bocavirus (16.1%) were commonly detected, but were not associated with sLRI risk. Co-infection with multiple viral species was associated with 2.92-fold greater odds of sLRI (95% CI, 2.05-4.16) compared to single viral species infections. Rhinovirus-bocavirus was the most common co-infection, and interaction between these viruses was associated with increased odds of sLRI.

conclusionsDiverse viral pathogens drive early-life sLRIs. Some (e.g. RSV and metapneumovirus) have an intrinsic propensity to cause sLRIs, while other viruses' lower airway pathogenicity depends on other factors, including co-infection.

Indexed as

Respiratory Tract InfectionsVirus DiseasesVirusesChild, PreschoolFemaleHumansInfantInfant, NewbornMalePuerto RicoRespiratory Syncytial Virus InfectionsSARS-CoV-2CoinfectionInfantsPediatricsRespiratory syncytial virus infectionsRespiratory tract infectionsRhinovirus

Identifiers

PMID41015263
PMCPMC12885233

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.