ReviewJournal of assisted reproduction and genetics2025
The role of sperm DNA fragmentation in reproduction: a SWOT analysis.
Review in Journal of assisted reproduction and genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMale factors account for up to 50% of infertility cases worldwide. Among the various etiologies, sperm DNA damage has received increasing attention through extensive research on sperm function tests. However, recommendations for its routine inclusion in infertility assessment remain unclear, and the clinical scenarios where such testing may be beneficial are still uncertain.
objectiveTo evaluate the implications of sperm DNA damage testing and treatment in reproductive medicine. STUDY
designA SWOT (Strengths, Weaknesses, Opportunities, and Threats) analysis was conducted to assess the screening and management of sperm DNA fragmentation (SDF) in infertile men. Evidence from the reviewed literature was graded according to Oxford criteria for clinical studies to ensure objectivity.
resultsSDF may contribute to certain cases of male infertility; however, reproductive outcomes are strongly influenced by additional factors, particularly oocyte quality and the method of conception. The absence of standardized cut-off values and low reproducibility across available assays represent major limitations. These weaknesses restrict the clinical utility of SDF testing, potentially increase healthcare costs, and may lead to inappropriate treatments.
conclusionSDF testing may provide insights into male infertility, but its clinical application is currently limited. Well-designed randomized controlled trials are needed to clarify its role and to establish evidence-based recommendations for its integration into assisted reproductive protocols.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.