ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025
Dampness syndrome aggravates T helper 17/regulatory T imbalance to promote renal injury in rats with experimental membranous nephropathy.
Shan Wenjun, G U Haowen, Guan Haiyu, L I Ping, Wang Yi, Han Miaoru, Wang Houchun, Huang Xiaoyan, Bao Kun
Abstract read
In one paragraphArticle in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Shan WenjunGuangzhou University of Chinese Medicine, Guangzhou 510145, China.
G U HaowenGuangzhou University of Chinese Medicine, Guangzhou 510145, China.
Guan HaiyuGuangzhou University of Chinese Medicine, Guangzhou 510145, China.
L I PingState Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Wang YiGuangzhou University of Chinese Medicine, Guangzhou 510145, China.
Han MiaoruGuangzhou University of Chinese Medicine, Guangzhou 510145, China.
Wang HouchunGuangzhou University of Chinese Medicine, Guangzhou 510145, China.
Huang XiaoyanState Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Bao KunState Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Funding
a Cohort Study on the Pathogenesis and Evolution of Dampness Syndrome in Idiopathic Membranous Nephropathy and Its Material Basis SZ2021ZZ09a Multimodal Machine Learning Prediction Model based on Pathological Images, Transcriptomics and Traditional Chinese Medicine Syndromes to Explore the Prognosis-related lncRNA Molecules of Membranous Nephropathy and the Intervention Mechanism of Sanqi Qushi Decoction 2025A03J4062China Postdoctoral Science Foundation Funded Project: Study on the Mechanism of Shenmai Injection in Promoting Angiogenesis after Myocardial Infarction in Rats with Qi and Yin Deficiency Type Diabetic Nephropathy 2023M730810Funding Project of Guangdong Provincial Administration of Traditional Chinese Medicine: Study on the Mechanism of "Dampness Stagnation in Blood Collaterals" inducing Vascular Aging Based on Oxidative Stress-inflammation Crosstalk and Intervention of Traditional Chinese Medicine 20233021Multi-omics Study to Explore the Material Basis of Dampness Syndrome in Membranous Nephropathy and the Intervention Mechanism of Sanqi Qushi Decoction 2024A03J0117Post-doctoral Research Project of Guangdong Provincial Hospital of Chinese Medicine: Study on the Mechanism of Yinyang Shengmai Method in Regulating Myocardial Infarction in Diabetic Rats based on Ang/Vascular Endothelial Growth Factor-Mediated Angiogenesis 10814Research Project of Guangdong Provincial Hospital of Traditional Chinese Medicine: Construction of a Risk Management Prediction Model for Membranous Nephropathy Based on Artificial Intelligence Technology YN2023HL03Special Project of State Key Laboratory of Dampness Syndrome of Chinese Medicine: a Randomized Controlled Clinical Study of Sanqi Qushi Granules in the Treatment of Membranous Nephropathy SZ2021ZZ36Study on the Pathogenesis Evolution and Microbiological Mechanism of Membranous Nephropathy with Dampness Syndrome Based on the Changes of Tongue Coating Microecology YN2023MB10the Guangzhou Science and Technology Plan Project: Exploring the Mechanism of Treating Membranous Nephropathy based on Dampness from the Perspective of Regulating Amino Acid Metabolism Disorders 2023A03J0746the National Natural Science Foundation of China: Research on the Role of Damp Nephropathy based on the Metabolic Disorders-T helper 17/Regulatory T Imbalance Evil in the Progression of Membranous 81974565
6 · The paper itselfAbstract
objectiveTo examine the T helper 17 (Th17)/regulatory T (Treg) immune balance in passive Heymann nephritis (PHN) rats with dampness syndrome (DS).
methodsRats were divided into four groups: normal control (NC), PHN model, PHN + DS model, and DS model. The DS model was created by administering lard, a 60% cold sucrose solution, and Chinese Baijiu
resultsThis study demonstrated a significant increase in proteinuria and total cholesterol levels in PHN rats with DS, along with more severe histopathological kidney damage. DS exacerbated podocyte damage in PHN rats. Additionally, the number of Treg cells was significantly reduced, while the ratio of Th17/Treg cells was significantly elevated in PHN rats with DS.
conclusionIn conclusion, the findings of our study indicate that the presence of DS exacerbates renal injury in PHN, a rat model used to simulate experimental membranous nephropathy. This observation may be closely linked to the exacerbation of the Th17/Treg imbalance and podocyte injury in PHN rats induced by DS.
Indexed as
Glomerulonephritis, MembranousKidneyTh17 CellsT-Lymphocytes, RegulatoryAnimalsDisease Models, AnimalHumansInterleukin-17Interleukin-6MaleRatsRats, Sprague-DawleyTransforming Growth Factor beta1Interleukin-17Interleukin-6Transforming Growth Factor beta1dampness syndromeglomerulonephritis, membranousTh17 cellsT-lymphocytes, regulatory
Identifiers
PMID41015801
PMCPMC12453988
What Socratic holds
Textmetadata
Read underepoch 390