Evidence map›Paper›PMID 41016194›Full record

Trial reportSleep medicine2025

Procedural learning worsens with OSA severity in older adults and is insensitive to short exposure supplemental oxygen therapy.

Christian D Harding, Breanna M Holloway, Pamela N DeYoung, Crystal Kwan, Ina Djonlagic, Sonia Ancoli-Israel, Xiaoying Sun, Sonia Jain, Sarah J Banks, Atul Malhotra

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Sleep medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christian D HardingDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, University of California San Diego, La Jolla, CA, United States.
Breanna M HollowayDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, University of California San Diego, La Jolla, CA, United States; Department of Psychiatry, University of California San Diego, La Jolla, CA, United States.
Pamela N DeYoungDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, University of California San Diego, La Jolla, CA, United States.
Crystal KwanDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, University of California San Diego, La Jolla, CA, United States.
Ina DjonlagicBeth Israel Deaconess Hospitals, Harvard Medical School, Boston, MA, United States.
Sonia Ancoli-IsraelDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United States.
Xiaoying SunBiostatistics Research Center, Herbert Wertheim School of Public Health, University of California San Diego, La Jolla, CA, United States.
Sonia JainBiostatistics Research Center, Herbert Wertheim School of Public Health, University of California San Diego, La Jolla, CA, United States.
Sarah J BanksDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United States; Department of Neurosciences, University of California San Diego, La Jolla, CA, United States.
Atul MalhotraDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, University of California San Diego, La Jolla, CA, United States. Electronic address: amalhotra@health.ucsd.edu.

Funding

Fellowship on Biological Psychiatry and NeuroscienceT32MH018399 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pei-an (Betty) Shih · 1986 to 2026
$7.3M
Is Obstructive Sleep Apnea Important in the Development of Alzheimer's DiseaseR01AG063925 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2020 to 2024
$3.7M
Underlying mechanisms of obesity-induced obstructive sleep apneaR01HL148436 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2020 to 2026
$3.4M
Sleep Apnea Endophenotypes: One Size Does Not Fit AllR01HL154926 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2021 to 2025
$3.3M
The cardiovascular consequences of sleep apnea plus COPD (Overlap syndrome)R01HL166485 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2023 to 2026
$3.1M
VentNet: A Real-Time Multimodal Data Integration Model for Prediction of Respiratory Failure in Patients with COVID-19R01HL157985 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, NEMATI, SHAMIM · 2022 to 2025
$2.9M
Developing a Diverse Next Generation of Leaders in Respiratory ScienceT32HL166127 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Laura Elise Crotty Alexander, Atul Malhotra · 2023 to 2026
$1.6M
NHLBI NIH HHS R01 HL148436NHLBI NIH HHS R01 HL154926NHLBI NIH HHS R01 HL157985NHLBI NIH HHS R01 HL166485NHLBI NIH HHS T32 HL166127NIA NIH HHS R01 AG063925NIMH NIH HHS T32 MH018399
6 · The paper itself

Abstract

STUDY

objectivesObstructive sleep apnea (OSA) has been associated with cognitive deficiencies in young and middle aged adults but the impact on cognition in older adults, who are at greater risk of age-related cognitive decline, is less well understood. We investigated how OSA severity impacts cognitive performance in older adults and whether short exposure to supplemental oxygen can modify this relationship, whilst also leveraging pathophysiology to identify oxygen treatment candidates.

methods65 participants (65+ years) not currently receiving OSA treatment were recruited from the San Diego community, most of whom presented with moderate or severe OSA. Participants undertook two nights of in-laboratory polysomnography under room air or nocturnal oxygen supplementation (NOS) conditions in randomized order. Participants performed sleep-dependent cognitive tests both before and after sleep.

resultsNocturnal hypoxemia was reduced with NOS treatment. There was no reduction in the frequency of apnea-hypopnea events (AHI) in the full sample, however we found a significant treatment effect on AHI among participants with OSA severity >15 events/hour or among those with below-median pharyngeal collapsibility. Motor sequence task improvement was negatively correlated with AHI within a night but NOS treatment did not improve performance between nights in either the full sample or a responsive sub-group.

conclusionsAs in younger adults, more severe sleep apnea is associated with worse motor procedural learning in older adults. However, a single night of NOS treatment had no effect on procedural learning, suggesting that OSA-related cognitive deficits result from chronic impacts of sleep disruption and hypoxia.

Indexed as

LearningOxygen Inhalation TherapySleep Apnea, ObstructiveAgedCognitive DysfunctionFemaleHumansHypoxiaMalePolysomnographySeverity of Illness IndexCognitionEndotypesLearningSleep apneaSupplemental oxygen

Identifiers

PMID41016194
PMCPMC12674969

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.