The medial septum-hippocampus-lateral septum circuitry in spatial memory: linking healthy function to early Alzheimer's disease and translational opportunities.

Yujie Song, Junjun Ni, Hong Qing, Zhenzhen Quan

Abstract readReview

In one paragraph

Review in Translational neurodegeneration, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Yujie SongKey Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.

Junjun NiKey Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China. Ninijunjun@bit.edu.cn.

Hong QingKey Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China. hqing@bit.edu.cn.

Zhenzhen QuanKey Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China. qzzbit2015@bit.edu.cn.

Funding

Beijing Nova Program 20220484083Beijing Nova Program 20230484436Ministry of Science and Technology of China STI2030-Major Projects 2022ZD0206800National Natural Science Foundation of China 82371441National Natural Science Foundation of China 82371446Natural Science Foundation of Beijing Municipality 7222113Natural Science Foundation of Beijing Municipality IS23093Shenzhen Science and Technology Innovation Program JCYJ20230807142704008Shenzhen Science and Technology Innovation Program JCYJ20241202130511015State Key Laboratory of Brain Cognition and Brain-inspired Intelligence Technology SKLBI-K2025002

6 · The paper itself

Abstract

Hippocampus (HPC)-associated spatial memory deficits are one of the earliest symptoms of Alzheimer's disease (AD). Current pharmacological treatments only alleviate the symptoms but do not prevent disease progression. The emergence of neuromodulation technology suggests that specific neural circuits are potential therapeutic targets for AD. Current studies have analyzed the medial septum (MS)-HPC and the HPC-lateral septum (LS) circuitries separately. A comprehensive understanding of their synergistic effects and overall dysregulation in AD remains limited. In this review, we will integrate anatomical and functional evidence to give an overview of the role of the MS-HPC-LS circuitry in spatial memory, the mechanisms of AD-related dysregulation, and therapeutic strategies targeting the circuitry, specially focusing on molecular interventions (receptor modulation) and bioengineering strategies (circuit-specific stimulation).

Indexed as

Alzheimer DiseaseHippocampusSeptal NucleiSpatial MemoryAnimalsHumansNeural PathwaysTranslational Research, BiomedicalAlzheimer's diseaseGlutamate receptorsMedial septum–hippocampus–lateral septum neural circuitryNeuromodulationSpatial memorySynaptic dysfunction

Identifiers

PMID41016929

DOI10.1186/s40035-025-00511-7

PMCPMC12477818

What Socratic holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.