Spatial and temporal mapping of early alphaherpesvirus invasion routes into the mouse central nervous system.

Viktoria Korff, Issam El-Debs, Julia Sehl-Ewert

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In one paragraph

Article in Journal of neurovirology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Viktoria KorffDepartment of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Südufer 10, 17493, Greifswald-Insel Riems, Germany.ORCID http://orcid.org/0009-0001-1058-4842

Issam El-DebsDepartment of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Südufer 10, 17493, Greifswald-Insel Riems, Germany.

Julia Sehl-EwertDepartment of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Südufer 10, 17493, Greifswald-Insel Riems, Germany. julia.sehl-ewert@fli.de.ORCID http://orcid.org/0000-0002-3884-1943

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alphaherpesviruses such as Herpes Simplex Virus 1 (HSV-1) and Pseudorabies virus (PrV) invade the central nervous system (CNS) via peripheral nerves. While olfactory and trigeminal pathways are well-known, additional cranial routes remain underexplored. Using a PrV-∆UL21gfp/US3∆kin mutant in CD1 mice, we mapped early neuroinvasion (4-96 hpi) by immunofluorescence and RNA in situ hybridization. Viral antigen and lytic viral gene expression (UL19 RNA) were detected in the olfactory epithelium, vomeronasal organ, incisors, palate, olfactory bulb, and brainstem. These results indicate multineural CNS access involving olfactory (I), trigeminal (V), glossopharyngeal (IX), and hypoglossal (XII) nerves, highlighting this model's value for studying early alphaherpesvirus spread.

Indexed as

AlphaherpesvirinaeCentral Nervous SystemAnimalsAntigens, ViralFemaleGlossopharyngeal NerveHypoglossal NerveMiceOlfactory NerveSpatio-Temporal AnalysisTrigeminal NerveVirus Physiological PhenomenaAntigens, ViralMouse modelNeuroinvasionOlfactory routePseudorabies virusSpatial mappingTrigeminal route

Identifiers

PMID41017005

DOI10.1007/s13365-025-01278-3

PMCPMC12618451

What Socratic holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.