Evidence map›Paper›PMID 41017089›Full record

ReviewCurrent cardiology reviews2026

The Heart of Psoriasis: Cardiovascular Alterations and Common Inflammatory Mechanisms.

Elpidio Santillo, Luciano Marini, Lucio Cardinali

Abstract readReview
In one paragraph

Review in Current cardiology reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Plants (Basel, Switzerland) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Elpidio SantilloRehabilitative Cardiology Unit, Italian National Research Centre on Aging (INRCA-IRCCS), 63900, Fermo, Italy.ORCID 0000-0001-8914-1317
Luciano MariniRehabilitative Cardiology Unit, Italian National Research Centre on Aging (INRCA-IRCCS), 63900, Fermo, Italy.ORCID 0000-0003-0806-3172
Lucio CardinaliRehabilitative Cardiology Unit, Italian National Research Centre on Aging (INRCA-IRCCS), 63900, Fermo, Italy.ORCID 0000-0002-5159-4318

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis mini-review aims to investigate the shared pathophysiological mechanisms linking psoriasis to cardiovascular disease (CVD), with a particular emphasis on electrocardiographic and echocardiographic alterations in individuals affected by psoriasis.

methodsA comprehensive search of PubMed and Google Scholar was conducted for studies published between January 1980 and June 2025. The search included clinical trials, observational studies, reviews, and meta-analyses.

resultsThe pathogenesis of psoriasis shares several key features with CVD, particularly systemic inflammation and endothelial dysfunction. Psoriasis patients frequently exhibit electrocardiographic abnormalities, such as arrhythmias, including atrial fibrillation (AF), and structural cardiac changes, such as left ventricular diastolic dysfunction. These cardiovascular changes are often observed even in the absence of clinically manifest heart disease. DISCUSSION: Psoriasis significantly contributes to cardiovascular risk, even in patients without manifest CVD. Chronic inflammation, endothelial dysfunction, and metabolic disturbances are key factors contributing to the increased cardiovascular risk observed in these individuals. Furthermore, the presence of psoriatic arthritis may exacerbate these associations, highlighting the multifaceted nature of the disease.

conclusionEarly detection and management of cardiovascular alterations in patients with psoriasis are essential for mitigating their long-term cardiovascular burden. Targeting shared inflammatory pathways may represent a promising therapeutic strategy to improve both dermatological and cardiovascular health in this patient population.

Indexed as

Cardiovascular DiseasesInflammationPsoriasisEchocardiographyElectrocardiographyHeart Disease Risk FactorsHumansatherosclerosiscardiovascular diseaseechocardiographyelectrocardiographyinflammationPsoriasis

Identifiers

PMID41017089
PMCPMC13519570

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.