Evidence map›Paper›PMID 41017449›Full record

ReviewCurrent opinion in obstetrics & gynecology2025

Shaping the future of urogynecology through regenerative medicine.

Tatyanna Henderson, Karen L Christman, Marianna Alperin

Abstract readReview
In one paragraph

Review in Current opinion in obstetrics & gynecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tatyanna HendersonDivision of Urogynecology and Pelvic Reconstructive Surgery, Department of Obstetrics, Gynecology, and Reproductive Sciences.
Karen L ChristmanShu Chien-Gene Lay Department of Bioengineering.
Marianna AlperinDivision of Urogynecology and Pelvic Reconstructive Surgery, Department of Obstetrics, Gynecology, and Reproductive Sciences.

Funding

Prevention of pelvic floor muscle dysfunction with extracellular matrix hydrogelR01HD102184 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALPERIN, MARIANNA, CHRISTMAN, KAREN L · 2020 to 2024
$3.2M
Pathways underlying recovery of injured urethral sphincter and a novel regenerative biomaterial interventionR01DK128639 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALPERIN, MARIANNA, CHRISTMAN, KAREN L · 2021 to 2024
$2.2M
NICHD NIH HHS R01 HD102184NIDDK NIH HHS R01 DK128639
6 · The paper itself

Abstract

purpose of reviewThe etiology of urogynecologic conditions is multifactorial and complex. However, the inability of the host pelvic tissues to repair and regain their original function in response to various insults, including maternal birth injury or age-related changes in the endogenous regenerative potential, underlies the pathophysiology of the morbid pelvic floor disorders (PFDs). Regenerative medicine approaches are poised to not only treat but potentially prevent the development of these deleterious conditions, the prevalence of which continues to increase. We aim to highlight the existent work at the crossroads of urogynecology and regenerative medicine and to underscore areas in need for continued and novel investigations. RECENT

findingsRegenerative medicine techniques, including stem cell therapies, extracellular vesicles, secretomes, platelet-rich plasma, laser-based interventions, and bioinductive acellular scaffolds, are being studied in the context of urogynecology, with many showing promise in revolutionizing prevention and treatment of PFDs by enhancing constructive tissue repair. SUMMARY: Regenerative medicine techniques hold the key to changing the clinical paradigm in Urogynecology from reactive to preventive.

Indexed as

GynecologyPelvic Floor DisordersRegenerative MedicineUrologyFemaleHumansStem Cell TransplantationTissue Engineeringbiomaterialscellular therapiesextracellular vesicleslaserpelvic floor disordersplatelet-rich plasmaregenerative medicinescaffoldssecretomes

Identifiers

PMID41017449
PMCPMC12539273

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.