ArticleNeural regeneration research2026
Immune dysregulation and gut microbiota: Connection to health and disease development.
Article in Neural regeneration research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global research trends in enteric nervous system and gut microbiota: a bibliometric analysis (2005-2025).Frontiers in cellular and infection microbiology · 2026Pooled it
- Role of Microbial Toxins in Neurodegenerative Diseases: Insights and Future Perspectives.Biomolecules · 2026Review
- The Role of ProbioticsInternational journal of molecular sciences · 2026Review
- Fecal microbiota transplantation mitigates lipopolysaccharide-induced oxidative stress in weaned piglets by modulating gut microbiota and enhancing riboflavin metabolism.Journal of animal science and biotechnology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroinflammation is a key pathophysiological mechanism in various neurological diseases, such as Alzheimer's disease and neuropsychiatric disorders. This review article analyzes the role of inflammatory mediators and their signaling pathways in the pathogenesis of neurodegenerative diseases, focusing on the molecular mechanisms that promote neurodegeneration and hinder neural regeneration. Recent evidence suggests that alterations in inflammatory processes in the brain are associated with cognitive impairment, progressive neurodegeneration, and impaired synaptic plasticity. Activation of Toll-like receptors triggers an inflammatory cascade involving pro-inflammatory cytokines such as interleukins and tumor necrosis factor alpha, which significantly contributes to neuronal dysfunction and cell death. Furthermore, we are investigating how these neuroinflammatory processes interfere with neural regeneration mechanisms and the maintenance of central nervous system homeostasis. Neural biomarkers associated with inflammation are emerging as potential diagnostic tools and therapeutic targets for neurological diseases, particularly anxiety disorders and Alzheimer's disease. Both experimental and clinical studies suggest that interventions aimed at modulating neuroinflammation could be a promising therapeutic approach to promoting neuroprotection and stimulating neural regeneration. This review summarizes the latest research on the molecular mechanisms of neuroinflammation and its effect on brain function. It also highlights potential neuroprotective and regenerative strategies for treating neurological diseases.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.