ArticleCerebral circulation - cognition and behavior2025
Disentangling the contributions of cerebrovascular-related white matter integrity markers to cognitive aging.
Article in Cerebral circulation - cognition and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Glymphatic dysfunction in Alzheimer's disease: a systematic review and meta-analysis of the DTI-ALPS index as an imaging biomarker.Frontiers in aging neuroscience · 2026Pooled it
- Age, Multidomain Lifestyle Intervention, and White Matter Integrity: Secondary Analysis of the POINTER Randomized Clinical Trial.JAMA network open · 2026Trial
- Contributions of Gray Matter Microstructure to Differences in Fluid Cognition and Episodic Memory Across the Healthy Adult Lifespan.Human brain mapping · 2026Article
- Imaging markers of vascular cognitive impairment: Current advances and future directions.Cerebral circulation - cognition and behavior · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To determine the independent and joint associations of five markers of white matter integrity, including white matter hyperintensities (WMH), extracellular free water (FW), fractional anisotropy (FA), peak width of skeletonized mean diffusivity (PSMD), and Diffusion tensor image analysis along the perivascular space index (ALPS) on cognitive performance and its trajectory in cognitively diverse individuals. Methods: 574 participants from the University of California, Davis Alzheimer's Disease Research Center (UCD ADRC) longitudinal cohort, aged 77 ± 7 years received yearly comprehensive clinical evaluations and a baseline MRI exam. Baseline MRI measures, including WMH, FW, FA, PSMD, and ALPS, were computed for each individual and used as independent variables to explain baseline and change in episodic memory (EM) and executive function (EF) using linear regression with stepwise adjustment. Bayesian Model Averaging (BMA) was then applied to derive robust estimates of each marker's contribution to cognition and its longitudinal trajectory, accounting for their joint inclusion in the same model. Results: Analyses showed that higher baseline WMH, FW, and PSMD, as well as lower FA and ALPS, were significantly associated with poorer cognitive performance ( Conclusions: This study identified both cross-sectional and longitudinal associations between five markers of white matter integrity and cognitive performance and decline. Using BMA-a method designed to disentangle the specific contribution of each marker while accounting for multicollinearity-we found that, among the five markers, FW and WMH emerged as the most probable candidates to explain the course of cognitive decline in EM and EF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.