SynthesisFrontiers in oncology2025
Impact assessment of current knowledge gaps and mitigation strategies in clinical FLASH proton therapy through a systematic review.
Synthesis in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Commissioning and Validation of a Synchrocyclotron - Based Ultra-High-Dose-Rate Beamline for FLASH.International journal of particle therapy · 2026Article
- Harnessing the sparing effect of FLASH-RT: From phenomenon observation, radiophysical determinants to molecular mechanisms and synergistic strategies.Materials today. Bio · 2026Review
- Towards FLASH Radiotherapy in Lung Cancer: A Review on Preclinical Evidence and Technical Feasibility.Cancers · 2026Review
- Breathing-phase selection for gated proton therapy in lung cancer towards temporally targeted ultra-high dose rate delivery.Physics and imaging in radiation oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Following first clinical trials, the development of FLASH proton therapy (FLASH-PT) into a mature treatment modality is ongoing, while physical and biological conditions underlying the FLASH effect remain uncertain. Our aim is to assess the impact of these uncertainties on clinical FLASH-PT through a novel approach. Methods: A systematic literature review was conducted to collect relevant Results: In total, 14 preclinical and 27 treatment planning studies were identified. From these, 47 combined scores were reported in the impact assessment. A severe impact was found for patient selection in the context of radiobiological uncertainties for the robustness of the FLASH effect with respect to beam pauses and interruptions and for the evaluation of dose rate due to their importance in the treatment process combined with remaining unknowns. Moderate to insignificant impact was found for fractionation and FLASH-PT treatment delivery mode (transmission or Bragg peak beams), as these offer strategies to circumvent uncertainties. Overall, dose requirements, the use of multiple fields, and dose rate conditions emerged as the most crucial factors. Conclusions: Since uncertainties about the FLASH conditions hinder the utilization of its full pre-clinical potential in clinical practice, focusing future preclinical experiments to gain further phenomenological rather than only mechanistic insights on these aspects is recommended.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.