ArticleFrontiers in neurology2025
Impact of nitroglycerin on 28-day mortality in ischemic stroke patients: a retrospective cohort study using the MIMIC-IV database.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The impact of nitroglycerin (NTG) on short-term outcomes in ischemic stroke patients remains unclear. This study aimed to evaluate the association between NTG use-including route, timing, and duration-and 28-day in-hospital mortality. Methods: We conducted a retrospective cohort study of 3,434 ischemic stroke patients, including 356 who received NTG. Propensity score matching (1:1) was used to reduce confounding. Cox proportional hazards models, Kaplan-Meier analysis, and stratified analyses assessed the association between NTG use and mortality. Results: NTG use was associated with reduced 28-day mortality before (HR = 0.52, Conclusion: Intravenous drip NTG, started within 24 h and continued for 1-3 days, was significantly associated with lower 28-day mortality in ischemic stroke patients. These findings suggest a potential therapeutic window and warrant further prospective validation.
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