ReviewFrontiers in neurology2025
Therapeutic advances in type 1 myotonic dystrophy complicated with type 2 diabetes mellitus.
Review in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myotonic Dystrophy (DM) is a hereditary muscle disorder characterized by progressive muscle weakness, myotonia, and multi-system dysfunction. Based on clinical and genetic features, DM can be classified into Type 1 (Type 1 Myotonic Dystrophy, DM1) and Type 2 (Type 2 Myotonic Dystrophy, DM2), with DM1 being the most common subtype in adulthood. Diabetes, a metabolic disease, is defined by persistent hyperglycemia, typically resulting from insufficient insulin secretion or impaired insulin action. Among the various forms of diabetes, Type 2 Diabetes (T2DM) has the highest prevalence, accounting for approximately 90% of all cases. Research has shown that individuals with Myotonic Dystrophy Type 1 (DM1) often experience comorbid Type 2 Diabetes (T2DM), a phenomenon that not only significantly increases the clinical burden but is also closely associated with poor prognosis, severely impacting patients' quality of life. This review provides a comprehensive analysis of the latest research on insulin resistance in DM1 patients, shedding light on the underlying mechanisms of DM1-related T2DM. Additionally, it explores the common comorbidities shared by DM1 and T2DM, including those affecting the muscular, respiratory, cardiovascular, endocrine, and nervous systems, as well as cancer and depression. Finally, this article summarizes the most recent therapeutic strategies for managing DM1 with T2DM, focusing on glucose-lowering medications combined with emerging targeted therapies that address the core pathophysiology of DM1, showing promising preclinical outcomes. This review aims to provide a theoretical foundation for future research and clinical practice in the management of DM1 complicated by T2DM.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.